GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Propylene glycol monomethyl ether acetate
CAS：108-65-6
Result：
| ID: | 21C0008 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | - | - | - | - | - | − |
| 2 | Flammable gases （including chemically unstable gases） | - | - | - | - | - | − |
| 3 | Aerosols | - | - | - | - | - | − |
| 4 | Oxidizing gases | - | - | - | - | - | − |
| 5 | Gases under pressure | - | - | - | - | - | − |
| 6 | Flammable liquids | - | - | - | - | - | − |
| 7 | Flammable solids | - | - | - | - | - | − |
| 8 | Self-reactive substances and mixtures | - | - | - | - | - | − |
| 9 | Pyrophoric liquids | - | - | - | - | - | − |
| 10 | Pyrophoric solids | - | - | - | - | - | − |
| 11 | Self-heating substances and mixtures | - | - | - | - | - | − |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | - | - | - | - | - | − |
| 13 | Oxidizing liquids | - | - | - | - | - | − |
| 14 | Oxidizing solids | - | - | - | - | - | − |
| 15 | Organic peroxides | - | - | - | - | - | − |
| 16 | Corrosive to metals | - | - | - | - | - | − |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | - | - | - | - | - | − |
| 1 | Acute toxicity （Dermal） | - | - | - | - | - | − |
| 1 | Acute toxicity （Inhalation: Gases） | - | - | - | - | - | − |
| 1 | Acute toxicity （Inhalation: Vapours） | - | - | - | - | - | − |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | - | - | - | - | - | − |
| 2 | Skin corrosion/irritation | - | - | - | - | - | − |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
In a test involving 9 rabbits, conjunctival redness, chemosis, iritis and corneal opacity were observed following application of the substance. Mean scores were 0.8, 0.5, 0.1 and 0.2, respectively. All signs of irritation disappeared after 4 days. The effects were judged to be "slightly irritating" (SIDS (2000)). The substance was conclusively estimated to be slightly to moderately irritating (SIDS (2003)). Based on these data, the substance was classified into Category 2B. |
| 4 | Respiratory sensitization | - | - | - | - | - | − |
| 4 | Skin sensitization | - | - | - | - | - | − |
| 5 | Germ cell mutagenicity | - | - | - | - | - | − |
| 6 | Carcinogenicity | - | - | - | - | - | − |
| 7 | Reproductive toxicity | - | - | - | - | - | − |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects, Respiratory tract irritation） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
In an oral test in rats, observations included lethargy at all doses (500 - 10000 mg/kg) (SIDS (access on June 2008)). In a dermal test in rabbits, narcotic effects were also found as the main symptoms (DFGOT vol. 5 (1993)). In a 2-week inhalation test with mice, an acute change, degeneration of olfactory epithelium in the nasal cavities, occurred at dose levels of 16.2 mg/L and higher concentrations and the effect was more severe and more extensive in a dose-related manner. An inflammatory exudate was found in the lumen of the nasal cavities in some animals (SIDS (access on June 2008)). Based on these data, the substance was classified into Category 3 (narcotic effects, respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | - | - | - | - | - | − |
| 10 | Aspiration hazard | - | - | - | - | - | − |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | - | - | - | - | - | − |
| 11 | Hazardous to the aquatic environment （Long-term） | - | - | - | - | - | − |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |