GHS Classification Result （Revision of the past classification result）

Chemical Name：Nickel sulfate
CAS：7786-81-4

Result：
ID: 21C0013
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (2004))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance is "Not combustible" (ICSC (2004)) and it does not spontaneously ignite on contact with room temperature air.
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2004))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is considered to be stable against water since data are available that water solubility is 40.4 g/100 g water (25 degC) (Lide (88th, 2003)) through it is a metal compound.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance is inorganic compound containing oxygen which is chemically bonded to nickel or sulfur.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 46 mg/kg (male) and 39 mg/kg (female) (correspond to Category 2) (ATSDR (2005)); 500 mg/kg (correspond to Category 4) (ECETOC TR33 (1989)); 275 mg/kg (correspond to Category 3) (ECETOC TR33 (1989)) and 325 mg/kg (correspond to Category 4) (ECETOC TR33 (1989)) for rats, the substance was classified into Category 4since most of the values are in this category.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Although the result of a rabbit Draize test was reported (RTECS (2008)), the details of the result are not clear. Classification was not possible due to lack of data. As relevant information, in EU classification, the substance is classified into Xi; R38.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Since nickel and its compounds are classified into R42/43 in EU classification (EU-Annex I (access on Jan. 2009)), Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and respiratory tract sensitizer in DFG (MAK/BAT No.43 (2007)), the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The testing of 4140 patients with suspected contact allergic eczema revealed a nickel sensitization in 23.8% of women and 5.2% of men tested (DFGOT vol. 22 (2006)). In addition, nickel and its compounds are classified into R42/43 in EU classification, Category 1 for skin sensitizer in Japan Society For Occupational Health (JSOH), (Recommendations for allowable concentrations (2008)) and skin sensitizer in DFG (MAK/BAT No. 43 (2007)). Based on these data, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on negative results in rat spermatogonium chromosomal aberration test (in vivo germ cell mutagenicity test) (EHC 108 (1991)), rat bone marrow chromosomal aberration test and mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (EHC 108 (1991)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames test (EHC 108 (1991)), positive V79 cell gene mutation test (IARC 49 (1990)) and weakly positive mouse lymphoma test (EHC 108 (1991)).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the classifications of "Group 1" in IARC (IARC 49 (1999)), "Category 1" in EU classification (EU-Annex I (2009)), "1" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and "K" in NTP (NTP RoC (11th, 2005)), the substance was classified into Category 1A. Soluble inorganic nickel is classified into "A4" in ACGIH (ACGIH-TLV (2008)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a two-generation reproductive test in rats, there was no effect on the sexual function, fertility or histopathological findings in the reproductive organs. However, a significant increase in post-implantation losses, an increased number of dead pups at lactation day 0 and a decreased mean litter size were observed (ATSDR (2005)). In a multigeneration test involving exposure of rats in diet for 11 weeks prior to mating, during mating, gestation and lactation, a dose-related slight increase in the number of stillborn pups was observed (Hazard Assessment Report (CERI, NITE)). Although it is unknown whether parental general toxicity could be manifested at doses producing reproductive effects, the detrimental effects on reproduction were reported. The substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a report of pulmonary hemorrhage at 36.5 mg Ni/m3 (0.037 mg/L/2h; 4-hour equivalence: 0.018 mg/L/4h), which falls within the guidance value range for Category 1, following inhalation exposure in rats (ATSDR (2005)). Since the severity of the symptom is not clear, classification was not possible due to lack of other data. For health hazards, refer also to nickel chloride.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, male genitalia) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, male genitalia) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 13-week inhalation test in rats, chronic active pulmonary inflammation and increased segmented neutrophil numbers occurred at dose levels of >0.00006 mg Ni/L (female) and 0.00022 - 0.0004 mg Ni/L (male). Lymphocytosis, lymph node hyperplasia and atrophy of the olfactory epithelium were also observed at a dose level of 0.0004 mg Ni/L (male and female) (NTP TR454 (1996)). In a 2-year inhalation test in rats, lung lesions such as inflammatory lung lesions and fibrosis were observed at dose levels of 0.00006 mg Ni/L and/or 0.0001 mg Ni/L (male and female) (at 7 months, 15 months, the end of test). Lymphoid hyperplasia and atrophy of the olfactory epithelium were observed at a dose level of 0.0005 mg Ni/L (male and female) (at the end of test) (NTP TR454 (1996)). Since these findings in the nasal cavity and lung were noted at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system). In a 120-day oral test in male rats, effects on the testis were observed at 25 mg Ni/kg which falls within the guidance value range for Category 2. In a 35-day oral test in mice, atrophy of seminal vesicle, epididymis and central sperm duct was observed at 1.1 mg Ni/kg which falls within the guidance value range for Category 1. Based on the data, the substance was classified into Category 1 (male accessory sex appendages). For health hazards, refer also to nickel chloride.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 72h-EC50 = 0.75 mg/L for algae (Selenastrum) (Hazard Data Book for Chemical Substance (CERI), 1997).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water and bioaccumulative potential are unknown from which it is a metal compound though the bioaccumulative potential is low (BCF: <31) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1985).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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