GHS Classification Result

Chemical Name:Vanadium(III) oxide
CAS:1314-34-7

Result:
ID: 22A4005
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (GESTIS (Access on Apr. 2010))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (GESTIS (Access on Apr. 2010))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (GESTIS (Access on Apr. 2010))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (V), its water solubility is 0.01 g/100 ml (20 degC) (It does not dissolve readily in water.) (ICSC (J) (2006)). it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - The substance is inorganic compound containing oxygen, which is chemically bonded to the elements other than carbon or hydrogen. Based on the description that vanadium is a strong reducing substance (EHC (J) 81 (1997)), classification is no available.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 value of 5639 mg/kg bw (OECD TG 401, GLP-compliant) (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 value of > 2500 mg/kg bw (OECD TG 402, GLP-compliant) (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the rat LC50 value of 4 mg/L/4hrs (OECD TG 403, GLP-compliant) (IUCLID (2000)), the substance was classified as Category 4. According to the description of the state of solid (powder) (Merck, 14th (2006)), the test was thought to be conducted with dust, the criterion values for dust/mist were adopted.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data were available. As the information of the "List3" datum in the GHS classification guidance for the Japanese government, instillation of 5 microL resulted in moderate irritation in rabbit test (standard Draize test), but details were not provided (RTECS (2003)).
4 Respiratory sensitization Classification not possible - - - - As a result of the investigation of 120 people who were occupationally exposed to the dust containing this material and vanadium pentoxide, bronchial asthma developed in three persons in 1 to 5 years. In animal study, rabbit showed symptoms of the asthma reaction in repeated inhalation test. Based on these documents, the substance was reported as a sensitizer (NIOSH Publications 77 - 222 (1977)) . However, since only this document existed and it was the datum from the information source in the "List 2" in the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible".
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Because no in vivo test data available, the classification was not possible. As a reference, positive results in the chromosomal aberration test using CHO cells were reported (CICADs 29 (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Acute exposure to vanadium oxide dust revealed irritation in upper and lower respiratory tract, and rhinitis and pharyngitis occurred within 30 minutes to 12 hours after exposure. Cough, nasal discharge, sneezing, dyspnea, and substernal soreness occurred with more severe exposures (HSDB (2006)). Cleaners exposed to this substance or vanadium pentaoxide at concentrations of 2-85 mg/m3 showed respiratory irritation (HSDB (2006)). Based on these reports, the classification was determined as Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
As the effects on humans, it was reported that in 36 workers exposed to slag dust (containing 16.9% of this substance and 4.8 - 7.5% of vanadium pentaoxide) for 2 - 3 years, rhinitis, coughing, wheezing, palpitations during exercise, tiredness, and bronchopneumonia were observed (DFGMAK-Doc. Vol.4 (1992)). In the animal studies, the rabbits exposed to the aerosols (dust) of this substance at concentrations of 40 - 75 mg/m3/2hrs (converted value as that of 6hrs-exposure: 0.013 - 0.025 mg/L) revealed serious dyspnea and rapid respiration accompanied by sneezing or nasal discharge during inhalation, some of them followed by death (EHC 81 (1988), DFGMAK-Doc. Vol.4 (1992)). The remaining survivors recovered to normal within 4 - 5 hours after the stoppage of exposure (NIOSH Publications 77 - 222 (1977)). In consideration of information on human health as well as the results in the animal studies found within the guidance values for Category 1, the classification was determined as Category 1 (respiratory organs). Besides, although it was described that fatty degeneration of hepatocytes with partial necrosis was observed in the rabbits, and the hepatic degeneration was also observed in the rats under the same test condition as rabbit study (EHC 81 (1988)), these descriptions about the effects on the liver were not adopted as the evidence of classification because there was only this assessment report.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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