GHS Classification Result

Chemical Name:Trisodium phosphate
CAS:7601-54-9

Result:
ID: 22A4010
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non flammable (IUCLID (2000))
8 Self-reactive substances and mixtures Classification not possible - - - - This substance contains P-O group associated with self-reactive properties, but no data is available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not pyrophoric (IUCLID (2000))
11 Self-heating substances and mixtures Not classified - - - - Non flammable (IUCLID (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (Na), its water solubility is 80 g/L (IUCLID (2000)) and it is considered stable in contact with water. The substance was classified as "Not classified".
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - No oxidizing properties (IUCLID (2000))
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. It is reported that it may corrode steel and brass in wet state (HSDB (2009)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 value of > 2000 mg/kg (OECD TG 401) (IUCLID (2000)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification). Although other rat LD50 value of 4.8 mg/kg was documented (IUCLID (2000)), priority was given to the OECD Guideline-complied test data for the classification.
1 Acute toxicity (Dermal) Classification not possible - - - - The rabbit LD50 value of >= 2 mg/kg was documented (IUCLID (2000)). Since the category could not be specified from only this datum, the classification was not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The rat LC50 value of >= 2.16 mg/L (converted value as that of 4-hour exposure: 0.54 mg/L) was documented (IUCLID (2000)). However, because the class could not be specified from only this datum, the classification was not possible. Since the LC50 values (2.16 mg/L) was higher than the saturated vapor pressure concentration (1.82E-07 mg/L), the criterion values for dust/mist were adopted.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In addition to the description that aqueous solution of the substance is highly alkaline and may produce caustic burn (HSDB (2009)), it is reported that pH of 0.1% - 1% of solution is 11.5 - 11.9 (Merck, 14th (2006)). Based on the information, the substance was classified as Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
In addition to the description that aqueous solution of the substance is highly alkaline and may produce caustic burn (HSDB (2009)), it is reported that pH of 0.1% - 1% of solution is 11.5 - 11.9 (Merck, 14th (2006)). Based on the information, the substance was classified as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data were available. The evidence of carcinogenicity was not obtained in the 2-year oral toxicity study in mice to which chlorinated trisodium phosphate containing this substance and sodium hypochlorite as complex was administered (HSDB (2009)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - The classification was not possible due to lack of sufficient data. As relevant information, it was reported that although the toxicity of the substance was not investigated, it might theoretically be related only to its alkalinity (PATTY, 5th (2001)), and that acute exposure to the substance might cause irritation of the respiratory system with subsequent coughing and pain. It was also reported that in severe exposures, pulmonary edema might develop (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The classification was not possible due to lack of sufficient data. As relevant information, it was reported that although the toxicity of the substance was not investigated, it might theoretically be related only to its alkalinity (PATTY, 5th (2001)), and that chronic exposures might cause inflammatory or ulcerative changes in the mouth and possible gastrointestinal disorders (HSDB (2009)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 96h-LC50 = 28.5 mg/L for fish () (AQUIRE, 2011).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 since its acute toxicity is Category 3 and there are no adequate data on rapid degradation.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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