GHS Classification Result

Chemical Name:Aluminium trifluoride
CAS:7784-18-1

Result:
ID: 22A4014
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (1999))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (ICSC (1999))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (1999))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - This substance is classified as "Not classified" because its water solubility is 0.5 g/100 mL and it does not react with water ("No reaction" (Weiss, 1986)) though it contains a metal (Al).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - This substance is an inorganic compound containing halogen atoms, but no data is available.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the mouse LD50 value of 103 mg/kg (HSDB (2009)), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - The classification was not possible due to lack of sufficient data. It was reported that the substance was a severe eye irritant (HSDB (2009)) and aluminum fluoride revealed strong irritation to tissue (HSDB (2009)). However the ground data were not provided.
4 Respiratory sensitization Classification not possible - - - - Insufficient data were available. Asthma-like symptom with the reversible respiratory obstruction developed in three workers of the material production factory, but a poor description with details of exposure conditions or clinical course were reported (PATTY, 5th (2002)). There is mention that this report is only suggestive information and have to be confirmed (PATTY, 5th (2002)).
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Because no in vivo test data available, the classification was not possible. As relevant information, as for in vitro test, there are negative results in the Ames test (NTP DB (access on May 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the inhalation exposure test using rats during the gestation period, increased frequency of pre-implantation death of fertilized ovum was found. At the dose group of higher concentration, embryotoxic and teratogenic effects in fetuses were shown (HSDB (2009)). However, since data for the general toxic effects on parental animals are not available, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - The classification was not possible due to lack of sufficient data. As relevant information, as for the acute symptom after exposure to the substance, respiratory tract irritation was reported (HSDB (2009)) and was also referred to irritating to nose and throat (HSDB (2009)). However, no evidence was shown.
9 Specific target organ toxicity - Repeated exposure Category 1 (bone) Danger H372: Cause damage to organs through prolonged or repeated exposure (bone) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was reported that according to an epidemiological investigation on workers exposed to fluorides in aluminum smelting, most of 107 employees who worked under relatively higher exposure concentration developed fluorosis after 10 year's exposure, and that moderate to severe osteosclerosis, with limitation of spine mobility, was detected after 15 years of exposure (ACGIH (2001)). Additionally, it was also reported that no bone changes in a group of workers exposed at the average concentration of fluoride of 2.65 mg/m3, while such changes were detected at the average concentration of 3.38 mg/m3 (ACGIH (2001)). Furthermore, it was described in the other literature as follows: bone fluorosis with variable degrees was seen, i.e. an increase in bone density in the vertebra and pelvis, calcification of the ligaments of the pelvis in the case that fluoride was further absorbed into bone, calcification of the paraspinal and other ligamentous structures as well as about joints in the case of excessive and long-term exposure to fluoride, were noted (HSDB (2009)). Based on the information, the classification was determined as Category 1 (bone). Besides, the other finding was listed in the same literature describing that inhalation of fluoride possessed a potential hazard to workers in primary aluminum production, but the majority of workers were clinically unaffected and the case with clinical fluorosis was rare (HSDB (2009)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No appropriate data for classification are available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No appropriate data for classification are available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information