GHS Classification Result

Chemical Name：Ammonium metavanadate
CAS：7803-55-6

Result：
ID: 22A4016
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
5 Gases under pressure Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
6 Flammable liquids Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
7 Flammable solids Not classified - - - - Non flammable (PATTY (5th, 2001))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
10 Pyrophoric solids Not classified - - - - Non flammable (PATTY (5th, 2001))
11 Self-heating substances and mixtures Not classified - - - - Non flammable (PATTY (5th, 2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metal (V), its water solubility is 0.48 g/100 g (20 degC) (Lange (16th, 2005)) and it is considered that the substance doesn't react strongly with water.
13 Oxidizing liquids Not applicable - - - - Solid (crystalline powder) at room temperature (Merck (14th, 2006))
14 Oxidizing solids Classification not possible - - - - Inorganic compounds containing oxygen, which is chemically bonded to the elements other than carbon and hydrogen. Since no test results are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values of 218 mg/kg (male), 141 mg/kg (female), and 160 mg/kg (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 value of > 2500 mg/kg (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (crystalline powder) at room temperature (Merck, 14th (2006))
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the rat LC50 values of 2.61 mg/L/4hrs (male) and 2.43 mg/L/4hrs (female) (DFGMAK-Doc. 25 (2009), original literature: Monatshefte fur Chenmie (1994)), the substance was classified as Category 4. According to the description, the test was carried out with dust, therefore the criterion values for dust/mist were adopted for the classification.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the positive results in the dominant lethal test by oral administration to rats (in vivo heritable mutagenicity test in germ cells) (DFGMAK-Doc. 25 (2009)), it was classified as Category 1B. In other data, there were positive results in the chromosome aberration test and the micronucleus test using mouse bone marrow cells (in vivo mutagenicity test in somatic cells) (CICAD 29 (2001)). As relevant information, as for in vitro tests, positive results (PATTY, 5th (2001)) and negative results (ATSDR DRAFT (2009)) in the Ames test, negative results in the chromosomal aberration test using human lymphocytes (CICAD 29 (2001)), positive results in the chromosomal aberration test using Chinese hamster ovary cells (CICAD 29 (2001)), and positive results in the micronucleus test using human lymphocytes (CICAD 29 (2001)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the study, male rats, which were received test substance at the dose level of 20mg/kg bw/day via drinking water for 70 days, were mated with untreated females. In treated males, the weight of testes, epididymides, prostate and seminal vesicles was significantly lower than in control animals. The mating index and the fertility index were also reduced. In addition, in the study, females which were received at the dose level of 20mg/kg bw/day via drinking water from 14 days prior to mating through mating and during pregnancy and lactation period up to 21 days after birth, the estrous cycle was disturbed, the fertility, the number of implantation sites and the number of viable fetuses per animal were markedly reduced (DFGMAK-Doc. 25 (2009)). In both studies, reduced body weights and developmental disability in the offspring during perinatal and weaning period, skeletal and visceral anomalies, malformations (e.g. anophthalmia or microphthalmia) in partial offspring were observed. Although the incidence of the morphological defect was not significant in statistics, it was higher in the administering group. For parent animal's general toxicity, details were not found except that there was no influence in the weight gain. Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system) Danger H370: Causes damage to organs (respiratory system, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		One case report was reported. One worker, exposed to dust of this substance over 6 hours while shovelling dry powder into a bin, developed headache in the interior region of orbit, lacrimation, dry mouth, and green discoloration of the tongue within 2 hours of commencing work. On the third day after exposure, he developed wheezing, dyspnea, a cough, thereafter he revealed a small amount of hemoptysis over the following 2 weeks, of which dyspnea persisted for about 1 month (CICAD 29 (2001)). Moreover, it was also described in the other literature that in subjects with an acute occupational exposure to the dust of the mixture of vanadium pentaoxide and sodium metavanadate containing this substance, it was reported that a rhinitis with a sneezing or coughing, and an itching or burning sensation in the throat were seen as mild symptoms, irritation of the upper respiratory tract, bronchitis with expiratory dyspnea and bronchospasm as moderate symptoms, and in severe case bronchitis and bronchopneumonia were seen (PATTY, 5th (2001)). Based on these, the classification was determined as Category 1 (respiratory system). As the other remarkable symptoms, disorders of nervous system containing severe neurotic states or tremor of fingers and hands were described (PATTY, 5th (2001)). In the animal studies, neurophysiological effects containing disturbances of the central nervous system were reported following acute exposure by oral administration of dogs and rabbits to vanadium oxide and salts (IARC 86 (2006)), and acute toxic signs containing reduced motility extending to apathy, paralysis of hind legs, decreased sensitivity to pain and lacrimation were described as common symptoms exposed to vanadium compounds in rats (DFGMAK-Doc. 25 (2009)). Therefore, the classification was additionally determined as Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		No information was available for human case exposed to the substance itself. It was reported, however, that workers who were occupationally exposed to dust mixtures of the substance and vanadium pentaoxide caused signs of coughing and irritation of the mucous membrane of the respiratory tract (DFGMAK-Doc. 4 (1992)), and was reported in several reports that workers exposed to vanadium dusts occupationally revealed the symptoms as follows: bronchitis, bronchospasm, persistent cough, irritating symptoms of nasal mucosa, wheezing, rale, coarse crackles, greenish tongue, and dyspnea or palpitation at higher concentrations. In addition, the risk of occurrence of pulmonary emphysema was pointed out. (JSOH, Recommendations for allowable concentrations, vol. 45 (2003)). Thus, the classification was determined as Category 1 (respiratory system). Besides, regarding the toxicity studies on experimental animals using this substance, a significant increase in leukocyte counts was observed in 4-week drinking study with rats (PATTY, 5th (2001)), and decreases in erythrocyte number and hematocrit value in males were reported in another 4-week drinking study with rats (CICAD 29 (2001)). However, details of these findings were unknown due to limited study design as well as no histopathological evidence.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 13.5 mg/L for fish (Fundulus heteroclitus) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and data on rapid degradation are not available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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