GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Lithium sulfate
CAS：10377-48-7
Result：
| ID: | 22A4019 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | It is reported that sodium sulfate (7757-82-6) and potassium sulfate (7778-80-5) are not combustible (sodium sulfate: ICSC (2005), potassium sulfate: ICSC (2003)). This substance is classified as "Not classified" because it is also thought to be non-combustible. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | It is reported that sodium sulfate (7757-82-6) and potassium sulfate (7778-80-5) are not combustible (sodium sulfate: ICSC (2005), potassium sulfate: ICSC (2003)). This substance is classified as "Not classified" because it is also thought to be non-combustible. |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | It is reported that sodium sulfate (7757-82-6) and potassium sulfate (7778-80-5) are not combustible (sodium sulfate: ICSC (2005), potassium sulfate: ICSC (2003)). This substance is classified as "Not classified" because it is also thought to be non-combustible. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it contains a metal (Li), its water solubility is 34.2 mg/100 mL (Ullmanns (E) (6th, (2003)), and it is considered that the substance doesn't react strongly with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | This substance is an inorganic compound containing oxygen, but no data on its oxidizing property are available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 value of 613 mg/kg (RTECS (2005), original literature: Environmental Health Perspectives. No.1- 1972-106 (Suppl 2), 497, (1998)), the substance was classified as Category 4. [For health hazards, refer also to other lithium compounds.] |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible because no in vivo test data was available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data were available. As information on other lithium compounds, there are numerous reports about Ebstein's anomalies (congenital cardiovascular malformations) in neonates born from mothers who ingested the psychotropic drug containing lithium carbonate as an active ingredient during pregnancy (PIM 309F (2000), Birth Defects, 3rd (2000), HSDB (2007)), in addition, it is well known that lithium can pass through the placenta (KemI-Riskline NR 2002:16). In the precautions of medicines package insert, lithium is contraindicated in the pregnant or possibly pregnant women (Handbook of Japanese pharmaceutical drugs (2010)). In addition, it is also documented in an insert as a direction for use that lithium is excreted into the mother's milk with a similar concentration in the serum (PIM 309F (2000)) so that suckling should be discontinued when administering to the breastfeeding woman is unavoidably executed (Handbook of Japanese pharmaceutical drugs (2010)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data were available. As information on other lithium compounds, the therapeutic use of lithium carbonate as an active ingredient of psychotropic drugs might produce unusual toxic response depending on the blood lithium concentrations (KemI-Riskline NR 2002:16, Handbook of Japanese pharmaceutical drugs (2010)). According to a medical package insert, it was recommended to monitor the blood lithium concentration as a precaution of usage (Handbook of Japanese pharmaceutical drugs (2010)). Furthermore, it was reported that in patients receiving lithium therapy, severe neurotoxicity might occur which included impaired consciousness, delirium, ataxia, generalized fasciculation and extrapyramidal symptoms when the plasma lithium level would exceed over 2.5 mM, and that the toxicity might occur for a few days from a few hours (KemI-Riskline NR 2002:16). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data were available. As information on the other lithium compounds, it was reported that the therapeutic use of lithium carbonate as an active ingredient of psychotropic drug may occur side effects such as tremor, lethargy, and confusion (KemI-Riskline NR 2002:16, Handbook of Japanese pharmaceutical drugs (2010)). The occurrence of toxicity is related to the blood lithium concentration, and those included neurological toxicity ranging from hand tremor, muscle weakness to coma (KemI-Riskline NR 2002:16). In a follow up study about side effects in patients treated with lithium preparation, treatment-related side effects were reported to include tremor, subjective memory loss and loss of creativity (IUCLID (2000)). While as side effects other than nervous system, cases with polyuria, polydipsia, or nephrogenic diabetes insipidus were reported (KemI-Riskline NR 2002:16, Handbook of Japanese pharmaceutical drugs (2010)), and a possible occurrence of chronic renal failure was also described (KemI-Riskline NR 2002:16). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |