GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Magnesium nitrate hexahydrate
CAS：13446-18-9
Result：
| ID: | 22A4020 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | This substance contains chemical groups associated with explosive properties, however, it is judged to be as "Not classified" because it is classified as Division 5.1, PG III in UNRTDG (UN1474) and is not appropriate to explosives. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | This substance is classified as oxidizing solid (Division 5.1, PG III in UNRTDG (UN1474)). |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it contains a metal (Mg), its water solubility is 71.2 g/100 g H2O (Lide (90th, 2009)) and it is considered that the substance doesn't react strongly with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Category 3 |
|
Warning | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
It is judged as Category 3, because this substance is classified as Division 5.1, PG III (UNRTDG (UN1474)). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | The rat LD50 value of 5440 mg/kg was documented (HERA (2002)) as the anhydride. Based on its converted LC50 value of 9410 mg/kg calculated from the molecular weight as a hexahydrate, the substance was classified as "Not classified". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Insufficient data were available. The substance was reported to be strong skin irritant (HSDB (2003)), but there was no evidence based on the data. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
The substance was classified as Category 2B based on the documented case of "slightly irritating" resulted from tests on rabbit eyes (HSDB (2006)). The document that this substance is severe irritant to the eyes was reported (HSDB (2003)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Because no in vivo test data available, the classification was not possible. As relevant information, as for in vitro study, negative results in the DNA damage repair test using cultured cells were reported (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Because no data were available, the classification was not possible. As relevant information, the IARC (IARC Vol.94 (2010)) described that the evidence of carcinogenicity in human for nitrate in drinking water is uncertain. And also, it evaluates the carcinogenicity as "Group 2A" under conditions that nitrate or nitrite is nitrosated in vivo after oral ingestion. The comprehensive evaluation of the IARC describes as follows: There is an in vivo interconvertible cycle in humans that involves nitrate and nitrite. Nitrosating agents that arise from nitrite under acidic gastric conditions react readily with nitrosatable compounds, especially secondary amines and amides, to generate N-nitroso compounds. These nitrosating conditions are enhanced following ingestion of additional nitrate, nitrite or nitrosatable compounds. Some of the N-nitroso compounds could generate known carcinogens under these conditions. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
|
Danger | H370: Causes damage to organs (blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There were no reports for this substance itself on humans, however, as a related information about soluble nitrates, there is a case report as follows. In 15 soldiers who ingested sodium nitrate by mistake in replace of table salts appeared methemoglobinemia, 13 who ingested around 15g died, and 2 who ingested 5g survived (ECETOC TR 27 (1988)). Thus, the classification of the substance was determined as Category 1 (blood). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
As chronic toxicity of soluble nitrates, there were numerous case reports for increase in blood concentration of methemoglobin in infants who ingested nitrates from dietary source or water. And it was also reported that methemoglobinemia occurred in the patients treated with sodium and ammonium nitrate as diuretics, or in the patients treated ammonium nitrate as a protectant of urinary calculus (ECETOC TR 27 (1988)). Based on the information, the classification of the substance was determined as Category 1 (blood). Besides, the cardiac effect of nitrates was reported, however, it was considered to be a secondary effect by hypoxia caused by methemoglobinemia (EHC 5 (1978)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |