GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：p-Cymene
CAS：99-87-6
Result：
| ID: | 22A4033 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 47 degC (closed-cup) (Merck (14th, 2006)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. In addition, it is classified into Class 3, PGIII in UNTRDG (UN2046). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its auto ignition point is 436 degC (HSDB (2003)) and it is considered that the substance does not ignite at room temperature, the substance was classified as "Not classified". |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. As relevant note, it is reported that the usual container material has durability (Hommel (1996)). |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 value of 4750 mg/kg bw (JECFA 1121 (2006)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on the rat LD50 value of > 5000 mg/kg (RTECS (2009), original literature: HPV121 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aromatic Terpene Hydrocarbons (2002)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Based on the rat LC50 value of 27.5 mg/L/45min (converted value as that of 4-hour exposure: 5.16 mg/L/4hrs) (PATTY, 5th (2001)), the substance was classified as "Not classified". Since the toxicity value (27.5 mg/L) is higher than the saturated vapor pressure concentration (10.5 mg/L), the criterion values for mist were adopted. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | The substance was reported that contact with the substance could produce erythema, dryness and defatting as primary skin irritant property. The intensity was depending on the dose and duration of contact (HSDB (2003)). However, details were lacking, and specific data were not provided, thus the substance was classified as "Classification not possible". |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (JECFA 1121 (2006)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a description that exposure by inhalation in humans could produce fatigue, nausea, confusion and ataxia at 600 - 800 ppm, and systemic anesthetic action at 10000 ppm (HSDB (2003)), the substance was classified as Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | The classification was not possible due to lack of sufficient data. As relevant information, there was description that oral administration of 2 g/day to dogs revealed no serious toxic effects except for the only side effect of diarrhea (HSDB (2003)), however, classification was not possible due to presence of no valid data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Although it was reported that the aspiration of a small amount of this material may cause various chemical pneumonitis (HSDB (2003)), further information was not found. Thus, the classification was not possible due to lack of data. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 48h-EC50 = 1.9 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2 and it is suspected that its bioaccumulation potential is high from LogPow = 4.1 (PHYSPROP Database, 2011) though it is rapidly degradable (BOD degradation rate tested by OECD 301C: 88% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1987)). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |