GHS Classification Result

Chemical Name:6-Methyl-5-hepten-2-one
CAS:110-93-0

Result:
ID: 22A4038
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point reported 56 degC (closed-cup) (IUCLID (2000)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its auto ignition point is >= 250 degC (IUCLID (2000)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 values of 3570 mg/kg bw and 4100 mg/kg bw (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 value of > 5000 mg/kg bw (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Based on the rat LC50 value of > 13.96 mg/L/4hrs (converted value from > 6.98 mg/L/8hrs) (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified". The test concentration (6.98 mg/L) was higher than the saturated vapor pressure concentration (5.18 mg/L), the criterion values for dust/mist were adopted for the classification.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "slightly irritating" (SIDS (Access on Jun. 2010)) resulted from the rabbit test in which application of the undiluted substance for 20 hours caused only erythema and symptoms were all reversible in 48 hours.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In the rabbit test, scores of the Draize at 24 hours after the application were 1 for corneal opacity, 1 for conjunctival redness, 0 for chemosis, respectively. All signs of irritation were completely reversible within 8 days (SIDS (Access on Jun. 2010)). Based on the document, the substance was classified as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - No sensitization was reported in the modified Draize test using guinea pig, open epicutaneous test, and human maximization test, and concluded that the substance is not a sensitizer (SIDS(Access on Jun. 2010)). Based on the information, the substance was classified as "Not classified".
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test (in vivo mutagenicity test in somatic cells) using bone marrow cells by intraperitoneal administration to mice (SIDS (Access on Jun. 2010)). As relevant information, as for in vitro study, negative results in the Ames test were reported (SIDS (Access on Jun. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the developmental toxicity study by oral administration using pregnant rat during the organogenetic period, maternal general toxicity occurred at the highest dose level (1000 mg/kg/day), but no effects were observed in gestational and developmental parameters and findings of teratogenicity up to and including 1000 mg/kg/day (SIDS (Access on Jun. 2010)). In the 13-week repeated dose oral toxicity study in rats, the test compound caused testicular toxicity affecting spermatogenesis at the high dose level of 1,000 mg/kg bw/day (SIDS (Access on Jun. 2010)). Despite these results, the substance was classified as "Classification not possible", due to insufficient data regarding the effects on sexual functions and fertility in parental animals.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the rats administered orally at 1360 mg/kg bw or higher, the clinical symptoms containing apathy, atonia, dyspnea, abdominal and lateral position were noted with dose-dependent intensity. Recovery occurred in survivors within 5 days at the dose level of 4650 mg/kg bw or lower, and no abnormalities were detected at necropsy (SIDS (Access on Jun. 2010)). Another signs observed in rats administered orally in another study with the doses between 2000 and 5000 mg/kg/bw were immediate agitation followed by ataxia (SIDS (Access on Jun. 2010)). Furthermore, it was reported that dysequilibrium was noted immediately after exposure by inhalation with higher concentrations, but recovered one day after exposure (SIDS (Access on Jun. 2010)). Since the above symptoms occurred at higher doses and recovered relatively soon, the substance was classified as Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 3-month oral toxicity study with rats (OECD TG 408, GLP-compliant), it was reported that the effects were seen in all dose levels (50-1000 mg/kg/day), and the target organs were kidneys, liver and testes (SIDS (Access on Jun. 2010)). The effects on kidneys were induced for males in all dose groups by accumulation of alpha-2-microglobulin which was known to be a rat-specific phenomenon without a toxicological relevance in humans. As for the liver, increased liver weights associated with centrilobular hypertrophy of hepatocytes were observed in high dose (1000 mg/kg/day), and as for the effects on the testis a testicular atrophy was also observed in high dose group (1000 mg/kg/day), but these were not found in the control and any other treatment groups. As stated above, the effects on the liver and testis were not observed at the doses below the mid dose (200 mg/kg/day), and the mid dose was over the upper limit of the guidance values. While, the findings of the kidney were male-rat-specific, and not relevant to humans. Thus, "Not classified" was applicable for oral route, but as the effects in the other routes (inhalation, dermal) were unknown due to lack of sufficient data. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 96h-LC50 = 68 mg/L for fish (Leuciscus idus) (SIDS, 2005).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified as "Not classified" since it is rapidly degradable (BOD degradation rate tested by OECD TG301F: 91% (SIDS, 2005)) and its bioaccumulation potential is estimated to be low (Log Kow = 2.4 (SIDS, 2005)) though its acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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