GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：beta-Pinene
CAS：127-91-3
Result：
| ID: | 22A4043 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 36 degC (closed-cup) (GESTIS (Access on June. 2010)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its auto ignition point is 294 degC (The Solvent Pocket Book (1994)), it is considered that the substance does not ignite at room temperature. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 values of > 5000 mg/kg bw (JECFA 54 (2006)), 4700 mg/kg bw and > 5000 mg/kg bw (DFGMAK-Doc. 17 (2002)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on the rabbit LD50 value of > 5000 mg/kg bw (DFGMAK-Doc. 17 (2002)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. |
Based on the rat LC50 7.29 mg/L/4h (DFGMAK-Doc. 17 (2002)), the substance was classified into Category 3. According to the description that the test was conducted with saturated vapour pressure concentration, criterion values for vapours were adopted for the classification. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
The substance was classified as Category 2 based on the documented case of "moderately irritating" resulted from rabbit test (DFGMAK-Doc. 17 (2002)). As relevant notes, erythema and edema was reported for the patch test that applied 70 - 80% olive oil preparation liquid to 28 patients with the skin disease (DFGMAK-Doc. 17 (2002)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | It was documented that the substance caused irritation to eyes (HSDB (2009)), but there were not further details nor concrete data. Thus, the substance was classified as "Classification not possible". |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 based on the list of Frosch textbook of the contact allergen (Contact Dermatitis (4th, 2006)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo data. As relevant information, as for in vitro study, negative results in the Ames test were reported (JECFA 54 (2006)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | The classification was concluded as "Classification not possible" due to the criterion of "A4" in the ACGIH assessment (ACGIH (2003)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the developmental toxicity study, rats were administered mixture (Rowachol (R)) consisting this substance on days 9 - 14 of gestation, no significant increases in the incidence of external, visceral or skeletal malformations. However, placental weight and the numbers of implantations and live fetuses were reduced at high dose causing general toxicity in dams (JECFA 54 (2006)). However, toxic effect of the substance was not clear because the mixture was used in this study. Therefore, the substance was classified as "Classification not possible". |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
After exposure by inhalation to human volunteers, the subjects showed increased airway resistance and felt discomfort in the throat and airways (HSDB (2000)). Additionally, there was a description stating that beta-pinene was irritating to the respiratory system (HSDB (2009)), thus, the substance was classified as Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In the 14-day rats feeding study of the 80% formulation of this substance at the dose of 10 mg/kg/day, no deaths and no clinical signs of toxicity were reported. No effects on food consumption, body weight, organ weights and gross pathological abnormalities were also reported (JECFA 54 (2006)). Because only this test result was apparently insufficient for the basis of classification, the substance was classified as "Classification not possible". |
| 10 | Aspiration hazard | Category 1 |
|
Danger | H304: May be fatal if swallowed and enters airways |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the fact that the substance is a hydrocarbon and has a coefficient of kinematic viscosity of 1.8 mm2/s (coefficient of viscosity: 1.552 mPa*s (HSDB (2009)), density: 0.86 (Lide, 90th (2009))), the substance was classified as Category 1. In addition, in the ACGIH (2003), there is a description that beta-pinene was a turpentine oil and the aspiration of the substance into the lungs may cause chemical pneumonitis. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 96h-LC50 = 0.5 mg/L for fish (Pimephales promelas) (HSDB, 2009). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and it is suspected to be bioaccumulative (LogPow = 4.16 (PHYSPROP Database, 2011)). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |