GHS Classification Result

Chemical Name：Penta-1,3-diene
CAS：504-60-9

Result：
ID: 22A4045
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported -26 degC (closed-cup) (Sax (11th, 2004)) is > 23 degC, and initial boiling point reported 42degC (Howard (1997)) is > 35 degC, the substance corresponds to Category 2.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Although there are chemical groups (unsaturated bonds) present in the molecule associated with self-reactive properties, classification is not possible due to lack of additional data.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to liquid substances with low boiling points are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - In the limit study (OECD TG401, GLP-compliant) for rats at a dose of 5000 mg/kg, 7 in 10 animals died (LD50 value: < 5000 mg/kg) (SIDS (Access on Jun. 2010)). And it was reported that the estimated LD50 value was > 2000 mg/kg (SIDS (Access on Jun. 2010)). Therefore, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of > 3.2 g/kg (OECD TG402, GLP-compliant) (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified". And furthermore, no mortality was observed at the dose of 3.2 g/kg (SIDS (Access on Jun. 2010)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the rat LC50 value of > 20917 ppm/4hrs (OECD TG403, GLP-compliant) (58.2 mg/L/4hrs) (SIDS (Access on Jun. 2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" category in the UN-GHS classification). The test concentration (20917 ppm) was lower than 90% of the saturated vapor pressure concentration (532894 ppm), the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - In the acute dermal test using rabbits, 24-hour application of 3.2 g/kg of test substance caused moderate irritation (SIDS (Access on Jun. 2010)). However, due to the large amount of applied volume and the long duration of application time, the information was not appropriate for judgment of irritation potential of the substance. Thus, the substance was classified as "Classification not possible".
3 Serious eye damage/eye irritation Classification not possible - - - - It was reported that the substance could not estimate to be a severe eye irritant according to the data of the associated analogs (SIDS (Access on Jun. 2010)). But, the substance was classified as "Classification not possible" due to no data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus tests using bone marrow obtained from rats and mice that were exposed by inhalation (OECD TG474, GLP-compliant) (in vivo mutagenicity test in somatic cells) (SIDS (Access on Jun. 2010)). As relevant information, as for in vitro studies, negative results in the Ames test and gene mutation test using mouse lymphoma L5178Y cells were reported (SIDS (Access on Jun. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), there were no evidence of reproductive toxicity of parent animals and treatment-related developmental toxicity to pup was scarcely observed (SIDS (Access on Jun. 2010)). However, data for toxic effects on development consisting the teratogenicity in the examinations of fetuses at the end stage of the gestation period were insufficient. Therefore, the substance was classified as "Classification not possible"
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description that the threshold concentration of the substance for humans which had irritativeness on the airways and caused symptoms of hypoxia was 850 - 1000 mg/m3, the substance was classified as Category 3 (respiratory tract irritation). As relevant information, it was reported that clinical signs after the exposure to rats at 17.8 mg/L/4hrs by inhalation included salivation and agitation (IUCLID (2000)). But it was not enough to classify based on this information only.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), no systemic effects were observed based on gross and microscopic evaluations of organs, and in no adverse effect level (NOAEL) was 1000 mg/kg/day, the highest dose level tested (SIDS (Access on Jun. 2010)). Based on this information, the classification was considered as "Not classified" in an oral route, but was concluded as "Classification not possible" due to lack of data in the other routes (inhalation, dermal).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" since all toxicity values exceeded 100 mg/L in acute toxicity tests for fish, crustacea and algae (SIDS, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 325.5 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information