Chemical Name：Butyltrichlorotin
CAS：1118-46-3
| ID: | 22A4052 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 81 degC (closed-cup) (HSDB (2010)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although it contains a metalloid (Sn), its water solubility is 8.2 g/L (CICAD 73 (2006)) and it is considered that the substance is stable in contact with water. |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | The substance is an organic compound containing chlorine which is chemically bonded to the element other than carbon or hydrogen. Since no test results are available, classification is not possible. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 value of 2140 mg/kg bw (EHC 15 (1980)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Insufficient data were available. The substance was reported as a strong irritant to human skin (HSDB (2010)). As the information from the "List 3" information source designated in the GHS classification guidance for the Japanese government, severe irritation was reported in the Draize test using rabbits (RTECS (2009)). However, no details were provided. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Insufficient data were available. As the information from the "List 3" information source designated in the GHS classification guidance for the Japanese government, severe irritation was reported in the Draize test using rabbits (RTECS (2009)). However, no details were provided. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results (NTP DB (Access on Jul. 2010)) and positive results (ATSDR (2005)) in the Ames test were reported. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data were available. As relevant information, the organic tin compounds were classified as "A4" in the ACGIH (ACGIH (2001)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the oral administration study in rats (rats were administered during GD7 - 17, dose levels: 0, 50, 100, 200 and 400 mg/kg/day), no developmental toxicity was evident at the dose in which no maternal toxicity was observed (CICAD 73 (2006)). In the oral administration study in rats (rats were administered by gavage at GD8 and 9, dose levels: 0, 1000, 1500 and 2000 mg/kg), no external malformations were found in the fetuses at the dose in which maternal toxicity was shown (CICAD 73 (2006)). In the oral administration study in rats (rats were administered by gavage on GD0 - 3, or GD4 - 7, dose levels: 0, 56, 226 and 903 mg/kg), the maternal toxicity was not reported. However, despite the slight increase in postimplantation loss was seen, the malformation was not seen (Teratogenic, 12th (2007)). Therefore, it was guessed that there was no teratogenicity. However, since no information was provided regarding sexual functions and fertility of parental animals, and insufficient data were available, the substance was classified as "Classification not possible". [See the results of classification of tributyl tin chloride (CAS: 1461-22-9) and tributyl tin oxide (CAS: 56-35-9).] |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | The classification was not possible due to lack of sufficient data. As relevant information, it was reported that in the gavage study in mice at 4000 mg/kg, fatty degeneration of the hepatocytes, enlargement of the liver, gastrointestinal hemorrhages, and hyperemia in the kidneys were observed (EHC 15 (1980), HSDB (2010), NIOSH Publications 77 - 115 (1976)). [See the results of the classification of tributyl tin chloride (CAS: 1461-22-9) and tributyl tin oxide (CAS: 56-35-9).] |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data were available. [See the results of classification of tributyl tin chloride (CAS: 1461-22-9) and tributyl tin oxide (CAS: 56-35-9).] |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3 from its 24h-EC50 = 49 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3 since its acute toxicity is Category 3 and data on rapid degradation are not available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |