GHS Classification Result

Chemical Name：2-Propoxyethanol
CAS：2807-30-9

Result：
ID: 22A4053
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 57 degC (closed-cup) (ICSC (J) (2003)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 230 degC (HSDB (2003), GESTIS (Access on July. 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of 3089 mg/kg (SIDS (2010), CICAD 67 (2009)) and 4400 mg/kg (CICAD 67 (2009)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The two LD50 values for rabbits of 900 mg/kg (CICAD 67 (2009)) and 1337 mg/kg (SIDS (2010), CICAD 67 (2009)) were reported. One corresponds to Category 3 and the other corresponds to Category 4. Selecting the category of greater hazard, Category 3 was adopted.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up. 		From the basis on the rat LC50 value of > 2132 ppm/6hrs (> 2612 ppm/4hrs) (SIDS (2010)), category can not be specified. However, based on the mouse LC50 value of 1530 ppm/7hrs (2024 ppm/4hrs) (DFGMAK-Doc 12 (1999)), the substance was classified as Category 3. Since the toxicity value was lower than 90% of saturated vapor pressure concentration (4105 ppmV), the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In the guinea pig test, occlusive application of maximum 20 mL/kg for 24 hours caused slight irritating, and symptoms were disappearing in a week (SIDS (2010)). The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) because the test was carried out with a large amount of substance and long application time.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2A based on the documented case of "moderate to strong irritation" (SIDS (2010)) resulted from the rabbit Draize test that instillation of 0.1mL of the substance caused severe erythema and moderate edema of the conjunctiva, iritis, and corneal opacity, but all symptoms disappeared within 14 days.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - No sensitization was reported in the Buehler test using guinea pigs (OECD TG406, GLP-compliant). In the skin sensitization tests using guinea pigs by injection to footpad, no sensitization was reported in one case (OECD TG406, GLP-compliant), and weak positive reaction in one of five animals was reported in the other case (SIDS (2010)). It was concluded that the substance was not sensitized for animals and humans, and not a skin sensitizer for guinea pigs (SIDS (2010)). Based on the information, the substance was classified as "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the developmental toxicity studies using rats and rabbits by inhalation during the organogenetic period, and in the developmental toxicity study in mice by oral administration during the organogenetic period, although decreases of food consumption and body weight gain were observed as maternal general toxicity, there were no teratogenicity and no adverse effects on the development of the offspring containing fetal toxicity for all species, except for increased skeletal variation rate for rats and rabbits (SIDS (2010)). However, since no information was provided regarding sexual functions and fertility of parental animals, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 1 (blood) Danger H370: Causes damage to organs (blood) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was reported that the main toxic symptom of this substance was hemoglobinuria caused by hemolytic effect, and that the symptom may occur even at oral doses of 195 mg/kg or lower especially in the rodents (DFGMAK-Doc 12 (1999)). Hematuria was observed in decedents in rats (LD50 value: 3089 mg/kg) and mice (LD50 value: 1337 mg/kg) following oral administration. In the inhalation study in rats exposed by vapors, reddish urine was observed in all animals at concentrations of 1100 ppm/6hrs (5.74 mg/L/4hrs) and greater, and hemoglobin concentration and hematocrit were reduced at all levels tested (250 - 2000 ppm) (SIDS (2010)). Because the effects were observed at 1100 ppm/6hrs (5.74 mg/L/4hrs) and above, corresponding to the level within Category 1 of the guidance values, and gross hemolysis was also observed (SIDS (2010)), the substance was classified as Category 1 (blood).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was described that the substance caused hemolysis of the erythrocyte in various species containing rats (PATTY, 5th (2001)). In the 6-week gavage study in rats, the effects were observed at the dose level of 195 mg/kg/day (converted dose level as that of 90-day study: 90 mg/kg/day) or more were as follows: reductions in hemoglobin concentration and erythrocyte count, hematuria and hemosiderin deposition in kidneys (SIDS (2010)). In the 14-week inhalation study in rats exposed to vapor, hemoglobinuria and the findings indicating hemolysis containing reductions in erythrocyte count, hemoglobin concentration and hematocrit values was observed at 200 ppm (0.852 mg/L) and above. As for histopathological findings, pigmentation in the kidneys, liver and spleen (presumably resulting from hemolysis) were observed histopathologically in these higher concentrations (PATTY, 5th (2001)). Based on these findings, because these doses which the effects were seen in both oral and inhalation routes existed within Category 2, the substance was classified as Category 2 (blood).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" since its 96h-LC50 for fish and 48h-EC50 for crustacea are 5000 mg/L or more (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not classified" and it is rapidly degradable (20d-BOD degradation rate: 100% (SIDS, 2004) and LogPow = 0.08 (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information