GHS Classification Result

Chemical Name：Tripropylene glycol methyl ether
CAS：20324-33-8,25498-49-1

Result：
ID: 22A4062
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point reported 113 degC (closed-cup) (25498-49-1 (mixed isomers), GESTIS (Access on July 2010)) is >= 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 277 degC (25498-49-1 (mixed isomers): SIDS (Access on July 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of 5460 mg/kg bw (SIDS (Access on Jul. 2010)) and 3200 mg/kg bw (ECETOC TR 95 (2005)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 values of 15440 mg/kg and > 19300 mg/kg (SIDS (Access on Jul. 2010)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - In the 1-hour inhalation study in rats, at 200 mg/L, no death was observed, and the LC50 value was estimated more than 200 mg/L (converted value as that of 4-hour exposure: 50 mg/L) (SIDS (Access on Jul. 2010)). It was also reported that there was not the actual value of exposure concentration, and the actual concentration may be lower than the nominal concentration (SIDS (Access on Jul. 2010)). However, the nominal concentration was very high and greatly exceeded the upper limit values of Category 4 (5 mg/L), therefore, the substance was classified as "Not classified". Since the test concentration (200 mg/L) was higher than saturated vapor pressure concentration (0.222 mg/L), it was judged the test was carried out in mist state.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test, 24-hour application of 0.01 mL of undiluted substance caused no irritation, and intensity of the irritation was grade 1 (maximum grade was 10) (SIDS (Access on Jul. 2010)). In other rabbit test, "mildly irritating" was reported (ECETOC TR64 (1995)). Based on these documents, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 or "Not classified" in the UN-GHS classification).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2A based on the documented case of "moderately irritating" (SIDS (Access on Jul. 2010)) resulted from the rabbit test that instillation of 0.1 mL of undiluted substance caused iritis in 1 of 5 animals and moderate corneal injury in all 5 animals, and irritation index was grade 4 (maximum grade was 10).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo data. As relevant information, as for in vitro study, negative results in the Ames test were reported (SIDS (Access on Jul. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the inhalation study using rats during the organogenetic period, apparently increased incidence of red staining around the muzzle was noted in the high exposure group as maternal general toxic effects. However, no treatment-related effects were observed in the gestational or developmental indices such as fertility index, number of live fetuses, early or late resorptions, and abnormality of fetuses, and these indices were comparable among all groups (SIDS (Access on Jul. 2010)). In conclusion, this substance did not show embryotoxicity or developmental toxicity. However, since sufficient information is not provided regarding sexual functions and fertility of parental animals, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		After oral administration at the dose levels between 2300 and 5000 mg/kg to rats, symptoms observed in survivors included crouching posture, lethargy, inactivity and unsteady gait, and coma and collapse added at higher doses (SIDS (Access on Jul. 2010)). Additionally, it was also reported that the symptoms following dermal application at 7720 - 19300 mg/kg to rabbits included unsteady gait, collapse and anesthesia (SIDS (Access on Jul. 2010), ECETOC TR 95 (2005)). Based on these clinical signs after treatment, the substance was classified as Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 2-week inhalation studies in rats and mice (mist, 0.15 - 1.01 mg/L/6hrs) (converted value as that of 90-day study: 0.023 - 0.155 mg/L/6hrs), no serious toxic damages were found, and the most remarkable findings in both species were increased liver weights without histopathological changes, which were considered as adaptive in nature (SIDS (Access on Jul. 2010)). While in the 90-day dermal application study in rabbits (dose levels: 965 - 9650 mg/kg/day), the only effects were narcotic reaction and deaths at the highest dose level of 9650 mg/kg/day, except local effects of skin reactions (SIDS (Access on Jul. 2010)). According to these results, although no serious effects were found in the 2-week inhalation studies in rats and mice, the classification was not possible because all the doses tested were within the guidance values. On the other hand, from the result that no serious effects were detected in the 90-day dermal application study in rabbits at the dose level beyond the range of the guidance values (965 mg/kg/day), the substance was classified as the category of equivalence to "Not classified" for dermal application. With regard to inhalation route, the classification was not possible due to lack of data. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information