GHS Classification Result

Chemical Name:sec-Butylamine
CAS:13952-84-6

Result:
ID: 22A4066
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point reported -9 degC (closed-cup) (ICSC (1999)) is < 23 degC and initial boiling point reported 63 degC (Merck (14th, 2006)) is > 35 degC, the substance corresponds to Category 2.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 378 degC (ICSC (1999)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Not classified - - - - Based on the information that steel and aluminum are durable as a container (Hommel (1996)), the substance was classified as "Not classified".

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
The two LD50 values for rats of 152 mg/kg bw and 380 mg/kg bw for the substance were reported (PATTY, 5th (2001)), one of which corresponds to Category 3 and the other corresponds to Category 4. Selecting the category of greater hazard, Category 3 was adopted.
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 value of 2500 mg/kg bw (JMPR 320 (1975)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - The rat LC50 value of 3.5 mg/kg bw was reported (JMPR 320 (1975)). However, since the exposure time was uncertain, the classification was not possible. Since LC50 value (3.5 mg/L) was lower than the saturated vapor pressure concentration (701 mg/L), it was judged the exposure was carried out with vapor.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the rabbit test, the substance was reported as a primary irritant (JMPR 320 (1975)), and the substance was classified as "C; R35" (EC-JRC (ESIS) (Access on Jul. 2010)). Based on these documents, the substance was classified as Category 1. As relevant notes, contact with human skin causes irritation or burns or dermatitis (HSDB (2008)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
The substance was classified into Category 1 because its preexisting classification for skin corrosion/irritation is Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The substance could not be classified due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (JMPR 539 (1981), NTP DB (Access on August. 2010)).
6 Carcinogenicity Classification not possible - - - - No data were available. As relevant information, in the 2-year feeding study of sec-butylamine acetate in rats, there is no description of the findings for tumor incidence (HSDB (2008)).
7 Reproductive toxicity Not classified - - - - Although there were no data of the substance concerned, the data regarding its acetate existed. In the four generation reproductive study by oral administration in rats, reproduction indices such as fertility index, gestation index, viability index and lactation index were normal (JMPR 320 (1975)). In the two-generation reproductive study by oral administration in rabbits, no effect on fertility, duration of gestation, delivery of live progeny or lactation indices were observed. There were no effects noted on survival of offspring in either generation (JMPR 320 (1975)). In the developmental toxicity study by oral administration in pregnant rabbits during the organogenetic period, the viability, which was evaluated using live fetus taken out at the end stage of gestation period by the incubation for 24 hours, decreased in comparison with the control group. However, there were no differences from controls with respect to reproduction, sex ratio or in the number of malformations observed (JMPR 320 (1975)). Because embryonic viability of rabbits was an item which was not performed in the usual developmental toxicity study, and the detail of the data was unknown, and the effect on survival of offspring was not observed in the two-generation reproduction study, therefore these descriptions were not adopted as the grounds for classification. As mentioned above, because there were no adverse effects on sexual functions and fertility of parental animals, and development of offspring, the substance was classified as the "Not classified" category.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
As the signs of toxicity in the acute oral toxicity study in rats (LD50 value: 380 mg/kg), following salivation, occurrence of convulsions and respiration paralysis were reported (JMPR 320 (1975)). In another acute oral toxicity study in rats (LD50 value: 152 mg/kg), sedation, loss of muscle coordination, rhinorrhea, gasping, and cramps were reported as poisoning symptoms (GESTIS (Access on August 2010)). Furthermore, there was a description that all amines examined showed stimulant action on central nervous system (PATTY, 5th (2001)). As stated above, although some data belonged to Category 1 judging from the guidance values, the information was obtained from the "List 2" information source designated in the GHS classification guidance for the Japanese government. Therefore, the substance was classified as Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although no data were available for the substance concerned, the data regarding its acetate existed. In the 3-month or 2-year feeding studies in rats, any treatment-related effects were not observed except for leukopenia and changes of some organ weights at the highest dose of 5000 ppm (converted dose into the substance concerned basis: 137 mg/kg/day) (JMPR 320 (1975)). Additionally, in the 2-year oral dose study in dogs, mydriasis was reported in all treated animals. Although lacrimation with keratitis occurred and all animals (4/4) died at the highest level of 250 mg/kg/day (converted dose into the substance concerned basis: 137 mg/kg/day), no treatment-related effects were noted at dose levels of 125 mg/kg/day (converted dose into the substance concerned basis: 69 mg/kg/day) or lower (JMPR 320 (1975)). The above results showed that no adverse effect occurred at the doses equivalent to those within the guidance values in both rats and dogs, and no toxic effects observed in rats treated even at the dose of 137 mg/kg/day which exceeded the range of the guidance values. Thus, the classification corresponded to "Not classified" for the oral route. While in the dermal route, no adverse reactions were reported in rabbits treated with 2 mL/kg/day (converted dose level as the substance concerned basis of 90-day study: 17.7 mg/kg/day) for 20 days. However, the information was inadequate to adopt for classification because the study was conducted with single dose level within the range of guidance values. No data were available for the inhalation route. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 96h-LC50 = 46-68 mg/L for fish (Leusiscus idus) (HSDB, 2008).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified as "Not classified" since it is rapidly degradable (28d-BOD degradation rate: 84, 94, 53% for NO2 and 109, 104, 68% for NH3 (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1980)) and its bioaccumulation potential is estimated to be low (Log Pow = 0.74 (PHYSPROP Database, 2011)) though its acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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