GHS Classification Result

Chemical Name：4-Ethylphenol
CAS：123-07-9

Result：
ID: 22A4080
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available. As relevant notes, UN2430 (ALKYLPHENOLS, SOLID, N.O.S. (including C2 - C12 homologues)) is rated as Class 8 by the UNRTDG.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - This substance is a solid whose melting point is lower than 55 degC, since no test results are available, classification is not possible.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the report that the administration of 2000 mg/kg to rats caused no mortality in both sexes and LD50 value was > 2000 mg/kg ("Toxicity Testing Report of environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)), the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on the report that the administration of 5000 mg/kg to rabbits caused no mortality and LD50 value was > 5000 mg/kg bw (HSDB (2003)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "mild irritation" resulted from the rabbit tests (HSDB (2003)) in which application of 0.5 mL/kg of test substance to 4 animals caused very slight erythema without edema in 2 animals and slight erythema with or without edema in 2 animals.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		The test substance was administered to 4 rabbits at the dose volume of 0.1 mL/kg. After 24 hours of application, severe eye irritation containing moderate to severe conjunctival irritation (redness, chemosis, discharge, necrosis), iritis, corneal opacity, stippling and ulceration was observed. By day 7 after application, severe irritation was still evident in all animals, one animal revealed pannus and one animal showed hair loss around the eye (HSDB (2003)). The substance was classified as Category 1 since these effects on eyes included irreversible symptom.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test using Salmonella and Escherichia (OECD TG471) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Aug. 2010)) and positive results in the chromosome aberration test using CHL/IU cells ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Aug. 2010)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No deaths occurred in both sexes of rats after single oral administration at 2000 mg/kg. As clinical signs, staggering gait followed by ventral position or lateral position, and tachypnea were observed and mean body weight values in the treatment group were significantly lower than those in the control group. But clinical signs recovered within 2 hours after administration, thereafter no treatment-related abnormalities were seen until day 14 after treatment. In addition, no treatment-related abnormalities were found in both sexes at necropsy performed on day 14 after dosing ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). Thus, these symptoms were not considered to be toxicologically significant. Therefore, for oral route, the classification corresponded to "Not classified" category. However, due to lack of sufficient data regarding the other routes, the classification for specific target organ toxicity (single exposure) was concluded as "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 28-day repeated dose oral toxicity study in rats, higher values of liver weight and a histopathological change as hyperplasia of squamous epithelial cells in forestomach at 300 mg/kg or higher, in addition to clinical signs such as staggering gait and salivation, lower values in body weight and food consumption, and higher values of kidney weight were found at 1000 mg/kg. Each change was recovered or tended to recover at the end of the recovery period. As a conclusion, the NOEL under this experimental condition was estimated to be 100 mg/kg/day (converted dose level as that of 90-day study: 31.1 mg/kg/day) for males and 300 mg/kg/day (converted dose level as that of 90-day study: 93.3 mg/kg/day) for females, respectively ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). Of the findings described above, the information of hyperplasia of squamous epithelial cells in forestomach at 300mg/kg and higher was not adopted for the basis for classification of specific target organ toxicity because it was caused by the irritating potency of the substance. In conclusion, it was difficult to consider the significant toxic effects based on the findings at 1000mg/kg (converted dose level as that of 90-day study: 311 mg/kg/day) with only slight clinical symptoms and changes in body weight and the organ weights. Thus, the classification corresponded to the "Not classified" category for oral route. However, no data were available to classify for the other routes, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 5.7 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since it is rapidly degradable (14d-BOD degradation rate: 90% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)) and its bioaccumulation potential is estimated to be low (LogPow = 2.58 (PHYSPROP Database, 2011)) though its acute toxicity is Category 2.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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