GHS Classification Result

Chemical Name：p-Nitrobenzoic acid
CAS：62-23-7

Result：
ID: 22A4084
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (nitro group) associated with explosive properties in the molecule. Since no test results are available, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (nitro group) associated with explosive properties in the molecule. Since no test results are available, classification is not possible.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is 300 degC (ICSC (2008)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - The substance is an organic compound containing oxygen which is bonded to nitrogen atoms, since no test results are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 1960 mg/kg bw (NTP TR 422 (1994)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not irritating" resulted from rabbit test (OECD TG 404, GLP-compliant) (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The substance was classified as Category 2B based on the documented case of "slightly irritating" resulted from rabbit test (OECD TG 405, GLP-compliant) (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" due to the negative results in the micronucleus test using peripheral blood obtained from mice administered by feeding (NTP DB (Access on Aug. 2010)), chromosome aberration test using bone marrow obtained from Chinese hamster administered by gavage, and micronucleus test using erythrocytes obtained from mice administered by gavage (IUCLID (2000)) (in vivo mutagenicity test in somatic cells). As relevant information, as for in vitro studies, positive results in the Ames test and the chromosome aberration test using CHO cells (NTP DB (Access on Aug. 2010)) and negative results in the HGPRT test using V79 cells (IUCLID (2000)) were reported.
6 Carcinogenicity Classification not possible - - - - Insufficient data were available. As relevant information, in the 2-year carcinogenicity studies in rats and mice by oral dietary administration, there was no evidence of carcinogenicity in male rats. On the other hand, increase in the incidence of adenoma of clitoral gland and in the combined incidence of adenoma and carcinoma of clitoral gland in female rats were noted, and it was considered to be certain evidence of carcinogenicity. However, in male and female mice, no evidence of carcinogenicity was found (NTP TR 442 (1994)).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the continuous breeding studies in mice by dietary administration from 7 days prior to copulation through 98-day cohabitation period, this substance caused dose-dependent impairment of both fertility and reproductive potential. Almost all reproductive parameters were adversely affected. In cross-over mating trial in which 0.75% groups were mated with the control group, adverse effects were observed in the fertility and reproductive potential. In the litters delivered from the dams in the 0.75% group which were cross-mated with control males, the number of live pups per litter and viability index of live born was significantly decreased. These findings showed the effects on the reproductive system for females. Reproductive performance of the second generation was also impaired and the response was very similar to the adverse effects noted in F0 animals (NTP RACB90065 Abstract (1990)). Since the effects mentioned above were observed in the middle dose groups (0.75%) in which the suppression of body weight gain did not occur as a general toxicity. Therefore, the substance was classified as Category 1B.
8 Specific target organ toxicity - Single exposure Category 2 (hematopoietic system) Warning H371: May cause damage to organs (hematopoietic system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral toxicity study in rats, infiltration of erythrocytes in the liver and myeloid metaplasia in the red pulp of the spleen were reported (NTP TR 422 (1994)). In addition, similar effects were observed in the oral toxicity study in mice (IUCLID (2000)). As relevant information, it was reported that methemoglobin formation and hematopoietic toxicity were found after administration of aromatic nitro or amino compounds, and this type of toxicity was often more severe in rats than in mice (NTP TR 422 (1994)). Based on these results described above and because the LD50 value (1960 mg/kg) was judged applicable to Category 2 of the guidance values, the substance was classified as Category 2 (hematopoietic system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 13-week feeding studies in rats and mice, as for rats, increased methemoglobin, Heinz bodies and reticulocyte counts, the changes of parameters in hematology characterized anemia were observed mainly at the higher dose level of 10000 ppm (660 - 680 mg/kg/day). And, congestion, pigmentation and accumulation of macrophages in the spleen were additionally observed at 2500 ppm (160 - 170 mg/kg/day) or higher doses. The doses of all these findings were over the range of the guidance values, and no description of the toxic effects within the guidance values was reported (NTP TR 442 (1994)). In the mice study, no test substance-related adverse effects were found up to the high dose level at 20000 ppm (4000 - 4900 mg/kg/day) except suppression of body weight gain. Furthermore, in the 2-year feeding studies in rats and mice, no test substance-related non-neoplastic adverse effects were observed up to 2500 ppm (100 - 125 mg/kg/day) for rats and 5000 ppm (675 - 905 mg/kg/day) for mice, respectively, which means no adverse effects attributed to the test substance were observed at doses over the range of the guidance values (NTP TR 442 (1994)). Based on these results, the category for the oral route was considered as applicable to "Not classified" category. However, the classification for specific target organ toxicity (repeated exposure) was conclusively determined as "Classification not possible" because of no toxicity information available for the other routes (inhalation, dermal).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified as "Not classified" from its 96h-LC50 > 500 mg/L for fish (Brachydanio rerio) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 200 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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