GHS Classification Result

Chemical Name：1,2,3-Benzotriazole
CAS：95-14-7

Result：
ID: 22A4094
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (adjacent nitrogen atoms) associated with explosive properties in the molecule. Since no test results are available, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (adjacent nitrogen atoms) associated with explosive properties in the molecule. Since no test results are available, classification is not possible. In addition, it is reported that the substance may detonate at 220 degC or during vacuum distillation (Sax (11th, 2004)).
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is 210 degC (ICSC (1998)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The three LD50 values for rats of 560, 600 and 965 mg/kg bw were reported (DFGMAK-Doc. Vol.2 (1991)), and all data correspond to Category 4. Thus the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 value of > 10000 mg/kg (HSDB (2003)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the rat LC50 value of 1.9 mg/L/3hrs (= 1.43 mg/L/4hrs) (PATTY, 5th (2001)), the substance was classified as Category 4. The acute toxicity value (1.9 mg/L) was higher than the saturated vapor pressure concentration (0.000158 mg/L) at room temperature, the criterion values for mist/dust were adopted.
2 Skin corrosion/irritation Not classified - - - - No skin irritation was reported in rabbit test (DFGMAK-Doc. Vol.2 (1991)). In other rabbit test, irritation scores both of erythema and edema were 0 in all observation time (Keml-Riskline (2000)). Based on these documents, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2 based on the rabbit test in which corneal opacity and redness of conjunctiva or iris were noted (DFGMAK-Doc. Vol.2 (1991)). As relevant notes, in another rabbit test, the irritation score was 81.0, and that after 26 days was 31.0. However, it was reported that these irritation scores were due to mechanical stimulus like the stimulation by sand (HSDB (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In the maximization test using guinea pigs, weak positive effects (1/20) were reported (Keml-Riskline (2000)). On the other hand, in other maximization test using guinea pigs, the negative result was reported (DFGMAK-Doc. Vol.2 (1991)). Because these test results were contradictory, the substance was classified as "Classification not possible". As relevant notes, in the maximization test in guinea pigs using the technical product, it was reported that weak positive reaction in 3 of 20 animals was shown. Thus, it was suggested that sensitization by occupational exposure might occur (DFGMAK-Doc. Vol.2 (1991)).
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (compliant to the OECD guidelines) (KemI-Riskline (2000)). As relevant information, as for in vitro studies, positive results were reported in the Ames test and the chromosome aberration test using CHO cells (NTP DB (Access on Sep. 2010)).
6 Carcinogenicity Classification not possible - - - - In the 104-week feeding study in mice, no tumors were observed in males. Vesiculobronchial carcinomas were observed in the low-dose group of females. But, because the incidences were not dose-dependent and were within the background data of the test facility, the effects were concluded to be no relation to the administration. In the 78-week feeding study in rats, neoplasms in nodules of the liver were significantly increased in high dose group of males, however, the effects were concluded to be no relation to the administration as compared to the background data of the test laboratory. In the same test, brain tumors were observed in all dose groups of males, however, it is insufficient to conclude that it was an evidence of carcinogenicity (NTP TR 88 (1978)). Endometrial stromal polyps without dose response seen in females were also concluded not treatment-related. (NTP TR 88 (1978), DFGMAK-Doc. Vol.2 (1991)). However, because the rat study was conducted during 78-week, the results could not adopt for the basis of classification. Therefore, totally, the classification was concluded as "Classification not possible" due to lack of data.
7 Reproductive toxicity Classification not possible - - - - In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity test in rats orally administered for 42 days for both sexes (OECD TG 422, GLP-compliant), no effects of the compound were observed on the copulation index, fertility index, number of corpora lutea of pregnancy, number of implantations, implantation index, number of pups born, number of live pups, delivery index, live birth index, and sex ratio. Thus, no adverse effects were observed on the sexual functions and fertility of parental animals (Safety Test Results (Ministry of Economy, Trade and Industry) (2007)). However, since data on development of the offspring were insufficient, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In the inhalation toxicity study in rats (LC50 value: 1.43 mg/L/4hrs), since clinical signs of deep abdominal breathing with open mouth gasping and severe hemorrhage in the lungs was observed at doses within Category 2 of the guidance values (HSDB (2003)), the substance was classified as Category 2 (respiratory organs). In the acute oral toxicity study in rats, depressed righting reflexes and analgesia were also observed. Based on the findings, Category 3 (narcotic effects) was added.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 8-week feeding study with rats, the only effect seen in the dose outside the guidance value of Category 2 was reduction of body weight gain (DFGMAK-Doc, Vol.2 (1991)). In the 42-day oral dose toxicity study in rats, several abnormalities in the parameters for hematology and clinical chemistry were observed in the doses outside of Category 2, while no relevant abnormalities were not seen in histopathology (Safety Test Results (Ministry of Economy, Trade and Industry) (Access on 2007)). Based on the reports described above, the classification corresponded to "Not classified" category in oral route, but was concluded as "Classification not possible" due to no information available for the other routes.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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