GHS Classification Result

Chemical Name：3-(4-Chlorophenyl)-1,1-dimethylurea
CAS：150-68-5

Result：
ID: 22A4096
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing chlorine and oxygen which are chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The two LD50 values for rats of 1480 mg/kg bw (NTP TR 266 (1988)) and 1480 - 3700 mg/kg bw (IARC vol.53 (1991)) were reported. Based on the value of 1480 mg/kg, the substance was classified as Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of > 2500 mg/kg bw (IARC vol.53 (1991)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant notes, it was reported that the substance was not irritant to the skin of guinea pigs (HSDB (2002)), however, no details were provided.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Insufficient data were available. As relevant notes, no sensitization was reported in guinea pigs (HSDB (2002)), however, no details were provided.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The positive results were reported in the micronucleus test using bone marrow obtained from mice by intraperitoneal administration (in vivo mutagenicity test in somatic cells) (IARC vol.53 (1991)). Besides that, the other positive results were found in the chromosome aberration test using bone marrow obtained from mice by intraperitoneal administration (in vivo mutagenicity test in somatic cells) (IARC vol.53 (1991)). Therefore, the classification was concluded as Category 2. As relevant information, as for in vitro studies, negative results in the Ames test, positive results in the chromosome aberration test using CHO cells and mouse lymphoma assay were reported (NTP DB (Access on Sep. 2010)).
6 Carcinogenicity Classification not possible - - - - The substance was classified as "Classification not possible" based on the criterion of "Group 3" in the carcinogenicity assessment by the IARC. As relevant information, in the 2-year feeding studies in rats and mice, increases in the incidences of tubular cell adenocarcinoma of the kidney and tubular cell adenomas of the kidney as well as neoplastic nodules or carcinomas of the liver in male rats were reported to be a clear evidence of carcinogenicity. However, it was reported that no evidence of carcinogenicity was found in females in rats and both sexes in mice (NTP TR 266 (1988)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 13-week feeding studies in rats and mice, the effects on the lymphocytes and hematopoietic system were observed in rats treated at 6000 ppm (300 mg/kg/day) or more and in mice treated at 12000 ppm (1800 mg/kg/day) or more, all of which were high doses over the range of guidance values (NTP TR No. 266 (1988)). However, in the 14-month feeding study in male rats administered at 250 - 1000 ppm (12.5 - 50 mg/kg/day), secondary anemia with increased methemoglobin formation and morphological changes of erythrocytes were observed. And hemosiderin deposition was histologically confirmed in the spleen, which was considered as reflecting the response to hemolytic anemia and methemoglobinemia. Pigment deposition was also observed in the kidneys and the liver (HSDB (2002)). Since these changes were seen at the applicable doses to Category 2 of the guidance values, the substance was classified as Category 2 (blood).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 26 mg/L for fish (Lepomis macrochirus) (AQUIRE, 2011).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (BIOWIN).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information