GHS Classification Result

Chemical Name：Tris(dichloropropyl) phosphate
CAS：13674-87-8

Result：
ID: 22A4097
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - The flash point 252 degC (Cleveland open cup) was obtained (HSDB (2003)), and it is estimated that the flash point measured by the closed-cup method is >= 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Although it contains P-O, this substance is phosphate and not phosphite (phosphorous acid) (- P-(-O-) 3). Therefore this substance is classified as "Not applicable" because there are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Although it contains a metalloid (P), its water solubility is 18.1 mg/L (SIAP (2009)) and it is considered that doesn't react strongly with water.
13 Oxidizing liquids Classification not possible - - - - The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen. Since no test results for oxidizing property are available, classification is not possible.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of 2236 mg/kg (male), 2359 mg/kg (female) and > 2000 mg/kg bw (OECD TG 401, GLP-compliant) (EU-RAR (2008)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on the report (EU-RAR (2008)) that the rat LD50 value was > 2000 mg/kg bw and the administration of 2000 mg/kg caused no mortality (OECD TG 402, GLP-compliant), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the report (EU-RAR (2008)) that the rat LC50 value was > 5.22 mg/L/4hrs and the exposure of 5.22 mg/L caused no mortality (OECD TG 403, GLP-compliant), the substance was classified as "Not classified". As the exposure concentration of 5.22 mg/L was higher than saturated vapor pressure concentration of 0.00000171 mg/L, the criterion values for mist were adopted.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test (OECD TG404, GLP-compliant) that 0.5 ml of test substance was instilled to 3 rabbits for 4 hours with semi-occlusive conditions, erythema (grade 2) was recorded in 2/3 animals after one hour and persisted for 24 hours in one animal. Erythema (grade 1) was noted in the third animal. There was no edema. All reactions disappeared within 48 hours (EU-RAR (2008)). Based on the document, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In the rabbit test (OECD TG405, GLP-compliant), application of 0.5 mL of test substance caused slight conjunctival erythema in all animals after 1 hour. These recovered by 24 hours. There were no other effects of treatment. Based on the document, the substance was classified as "Not classified" (EU-RAR (2008)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified as "Not classified" since in the guinea pig maximization tests (OECD TG 406, GLP-compliant), no skin sensitization was observed (EU-RAR (2008)). In addition, as the summary of the data obtained, there was a consideration that the substance was not a skin sensitizer (EU-RAR (2008)).
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow cells obtained from mice orally administered (OECD TG474, GLP-compliant) as well as the chromosome aberration test using bone marrow cells obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (EU-RAR (2008)). As relevant information, as for in vitro studies, positive results in the Ames test (EHC 209 (1998)), negative results in the chromosome aberration test using Chinese hamster CHO cells (OECD TG473, GLP-compliant) (EU-RAR (2008)), positive or false positive in the chromosome aberration test using mouse lymphoma L5178Y cells (EHC 209 (1998), EU-RAR (2008)), negative results in the chromosome aberration test using human fibroblast cells (EHC 209 (1998)), and negative or positive results in the gene mutation test using mouse lymphoma L5178Y cells (EHC 209 (1998), EU-RAR (2008)), were reported.
6 Carcinogenicity Classification not possible - - - - In the 24-month dietary carcinogenicity test in rats (dose levels: 5, 20 and 80 mg/kg bw/day), the high mortalities and the clearly low body weights were found in both sexes of the highest dose group at 80 mg/kg bw/day . In the same test, the significant increase in the incidences for adenomas in the renal cortex in both sexes and interstitial cell tumors of the testis in males at 20 mg/kg or more. The incidences of hepatocellular adenomas in both sexes and adenomas in the adrenal cortex in females at 80 mg/kg were also significantly increased. In addition, increase, but statistically insignificant, in the incidence of hepatocellular carcinomas was noted in both sexes with dose-dependency (SIAP (2009)). From these data, the significant increases in the incidences of adenomas in kidney, liver and other organs were recognized. However, the data were obtained from one animal species, therefore, the classification was concluded as "Classification not possible" due to lack of data.
7 Reproductive toxicity Not classified - - - - In the developmental toxicity study using pregnant rats orally administered during the organogenetic period, maternal toxicity such as significant decrease in the body weight gain and food consumption was observed, and death occurred at the highest dose (400 mg/kg bw/day), and significant increase in the incidence of resorption and delayed ossification were also observed. There was no increase in the fetal death, and neither abnormality of the fetal growth nor malformation was seen in the dose of 200 mg/kg or less (SIAP (2009)). Increased resorption was not adopted as the basis of classification, because of the influence of only at high dose levels seen significant maternal toxicity containing deaths. In addition, in the oral administrated study in rabbits for 12 weeks, in addition to indices on mating, fertility and pregnancy, numbers of corpora lutea, implantations, viable fetuses or resorption were unaffected by treatment (EU-RAR (2008)). Thus, no adverse effects on sexual function and fertility were observed. Therefore, the substance was classified as "Not classified".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the single dose oral toxicity study in rats (OECD TG401, GLP-compliant), in addition to occurrence of deaths, decreased respiratory rate, loss of righting reflex, vocalization were observed at 1710 mg/kg bw or higher (EU-RAR (2008)). In another single dose oral study in rats, deaths occurred at 2000 mg/kg with clinical signs of toxicity such as salivation, hypokinesia and ataxia (EU-RAR (2008)). The LD50 values of both studies were greater than 2000 mg/kg, clinical signs of toxicity were non-specific (EU-RAR (2008)). This document was not enough to adopt as the basis for classification due to lack of sufficient data, so the classification was determined as "Classification not possible". As relevant information, in the dermal application study in rats treated at 2000 mg/kg (OECD TG402, GLP-compliant), there were no mortalities and no clinical signs of toxicity, and no abnormality was detected at necropsy (EU-RAR (2008)). Similarly, in the single inhalation study in rats exposed at the concentration of 5.22 mg/L (OECD TG 403, GLP-compliant), there were no mortalities and no clinical signs of toxicity, and no abnormality was detected at necropsy (EU-RAR (2008)).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 24-month feeding study in rats, increase in the incidence of hyperplasia of the convoluted tubule epithelium in the kidneys, and the effects on the testes containing atrophy of germinal epithelium, oligospermia, or atrophy of seminal vesicles were observed in males treated at the dose level of 5 mg/kg/day (equivalent to Category 1 of the guidance values) or more (EU-RAR (2008)). Based on the findings, the substance was classified as Category 1 (kidney, testis).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 = 1.1 mg/L for fish (Oncorhynchus mykiss) (EU-RAR, 2008).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1980)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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