GHS Classification Result

Chemical Name：p-Anisaldehyde
CAS：123-11-5

Result：
ID: 22A4104
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Although measurement method of the flash point 121 degC is unknown (HSDB (2003)), it is estimated that the flash point measured by the closed-cup method is >= 93 degC. Therefore, the substance is classified as "Not classified".
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the report that the administration of 2000 mg/kg for rats caused no mortality, and the estimated LD50 value was > 2000 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2000)), the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of > 5000 mg/kg (BUA 250 (2004)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - It was reported that the rat LC50 values (male and female) were more than 0.32 mg/L (vapor) (SIAP (2009)). Since the exposure time was unknown, the classification was not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Negative results of human patch test were reported (SIAP (2009)). In the rabbit test, occlusive application of the substance caused slightly irritation after 4 hours of application, but symptoms were all disappeared within 8 days. Based on these documents, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).
3 Serious eye damage/eye irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "non-irritating" from rabbit test in which slight irritation was noted, but symptoms disappeared within 72 hours (SIAP (2009)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In the maximization test on 25 volunteers, the substance was not sensitizing. The result of the LLNA test (OECD TG 429 and EPA OPPTS 870.2600) using mice was also negative. The substance was concluded to be non-sensitizer to the skin (SIAP (2009)). Based on the document, the substance was classified as "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and in the chromosome aberration test using CHL cells ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on May 2010)) and others were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422), decrease of the fertility index, number of pups born, delivery index, and number of pups alive were noted at the dose (500 mg/kg) in which general toxicity such as transitory salivation and hypertrophy of hepatocyte to parent animals was observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Oct. 2010)). Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the acute oral toxicity study in rats (OECD TG 401), no treatment-related changes of clinical signs were observed in all treatment groups, and the values of body weight gain in both sexes at 2000 mg/kg were slightly decreased only on day 2 of observation. In the findings at necropsy conducted on day 15 of observation period, no abnormalities were observed in all animals ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Oct. 2010)). According to the results of the report, although classification was equivalent to "Not classified" category in oral route, the classification for specific target organ toxicity (single exposure) was concluded as "Classification not possible" because the effects for the other routes were unknown due to no data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422), the changes observed were as follows: increased liver weights, elevations of the liver-derived enzyme activities in the serum, and centrilobular hepatocellular hypertrophy at 500 mg/kg/day (converted dose level as that of 90-day study: approx. 235 mg/kg/day), significant decreases in platelet counts at 100 mg/kg/day (converted dose level as that of 90-day study: approx. 47 mg/kg/day) or more, and hyperplasia of squamous epithelium in the forestomach in all rats at 500 mg/kg/day and three rats at 100 mg/kg/day ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Oct. 2010)). However, the toxic effects at the upper limit of the guidance values (100 mg/kg/day) remained unknown due to lack of sufficient data. Therefore, the substance was classified as "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 40 mg/L for fish (Oryzias latipes) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1999).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since it is rapidly degradable (Readily biodegradable, BOD degradation rate: 99% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2001)) and its bioaccumulation potential is estimated to be low (Log Kow = 1.79 (PHYSPROP Database, 2009)) though its acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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