GHS Classification Result

Chemical Name：Methyl benzoate
CAS：93-58-3

Result：
ID: 22A4105
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 82 degC (closed-cup) (Merck (14th, 2006)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 518 degC (GESTIS (Access on Oct. 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on four LD50 values for rats of 1.35 g/kg (PATTY, 5th (2001)), 2200 mg/kg (JECFA WHO FOOD ADDITIVES SERIES 48 (2002), PATTY, 5th (2001), HPV EPA (2001)), 3400 mg/kg (JECFA WHO FOOD ADDITIVES SERIES 48 (2002), PATTY, 5th (2001), HPV EPA (2001)) and 3500 mg/kg (HPV EPA (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of > 2000 mg/kg (HPV EPA (2001)) and result of no mortality, the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the report that exposure of 1000 ppm/8hrs (5.57 mg/L/8hrs) for rats caused no mortality, and the LC50 value was > 1000 ppm/8hrs (converted concentration as that of 4-hour exposure: > 1410 ppm (7.8 mg/L)) (HPV EPA (2001)), the substance was classified as "Not classified". According to the description that the test was carried out at the saturated state, the criterion values for mist were adopted.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test, irritation score was 3 (Maximum score was 10) (PATTY, 5th (2001)), so the substance was considered as a slight irritant. Based on the document, the substance was classified as "Not classified" (corresponding to Category 3 in the UN-GHS classification).
3 Serious eye damage/eye irritation Not classified - - - - In the rabbit test, irritation score was 1 (maximum score was 10), and injury of the eyes were minimum (PATTY, 5th (2001)). The substance was classified as "Not classified" because the substance considered as a slight irritant.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In the rabbit test, non-occlusive application caused no erythema after 2 hours and 4 hours of application. After 24 hours of the second application, extremely slight erythema were noted and redness was increased with repeated doses. After the sixth dose, moderate to severe edema were noted (PATTY, 5th (2001))). However, the substance was classified as "Classification not possible" because insufficient data were available due to that no details were provided and test method was doubtful as a sensitization test.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (JECFA WHO FOOD ADDITIVES SERIES 48 (2002), NTP DB (Access on Oct. 2010), HPV EPA (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - The classification was not possible due to lack of sufficient data. As relevant information, in the acute oral toxicity studies in rats, mice, rabbits, or guinea pigs, the LD50 values of over 2000 mg/kg. And it was reported that clinical signs of toxicity observed in decedents included the effects on central nervous system such as tachypnea, piloerection, muscle incoordination, progressive paralysis of hind limbs, violent spastic convulsions, followed by dyspnea prior to death (HPV EPA (2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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