GHS Classification Result

Chemical Name：1,3-Diisopropylcarbodiimide
CAS：693-13-0

Result：
ID: 22A4123
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
5 Gases under pressure Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 31 degC (closed-cup) (MSDS (Sigma-Aldrich) (Access on Nov. 2010)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.
7 Flammable solids Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid at room temperature (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Nov. 2010)).
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data were available. As relevant notes, in the mouse test by non occlusive application of the substance, mild irritation was reported (RTECS (2007)), which was the "List 3" information source designated in the GHS classification guidance for the Japanese government.
3 Serious eye damage/eye irritation Classification not possible - - - - As for the human case report, a worker who was acute exposed to the vapor of the substance revealed hazy vision with pain after 12 to 18 hours of exposure. Symptoms were maximized 34 hours after the exposure, visual impairment occurred. But these damages remitted after 2 weeks of exposure. This transient visual impairment was caused by the damage to the outer layer of the cornea. (NTP TR 523 (2007)). It was also reported that this injury resembled mild to moderate injury by mustard gas (NTP TR 523 (2007)). Although the substance may have irritation to human skin as mentioned above, the classification was not possible due to lack of data of the ordinary eye irritation test.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 since the substance was reported as a skin irritant (Contact Dermatitis, Frosch, 4th (2006)).
5 Germ cell mutagenicity Classification not possible - - - - Although the micronucleus test using erythrocytes obtained from mice dermally administered for 3 or 4 months (in vivo mutagenicity test in somatic cells) revealed positive results (NTP TR 523 10 (2007)), the reaction was reproducible but its intensity was approximately twice that of the negative control. Also, positive result in the other micronucleus test using peripheral blood obtained from mice by single intraperitoneal administration (in vivo mutagenicity test in somatic cells) was reported (NTP DB (1995)). But the intensity of reaction was less than twice that of the negative control, and no clear dose response was shown. On the other hand, negative results were obtained in the micronucleus tests using bone marrow obtained from male mice and rats by intraperitoneally administered three times (in vivo mutagenicity test in somatic cells) (NTP DB (1995)). Conclusively, the positive results in every test described above were not clear response and no other sufficient data showing positive results classifiable to the Category 2 were reported. Therefore, the classification was concluded as "Classification not possible". As relevant information, as for in vitro studies, negative results (NTP DB (1994)) and equivocal results (NTP DB (2007)) in the Ames test were reported.
6 Carcinogenicity Classification not possible - - - - Insufficient data were available. As relevant information, in the 2-year dermal studies in rats and mice, no increases in the incidence of tumors in relation to the administration of this substance were found in both animals (NTP TR 523 (2007)). No data by other administration routes were reported.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 3-month dermal application studies in rats and mice, clinical signs such as convulsion, ataxia, abnormal breathing and lethargy were observed in rats at the dose levels of 80 mg/kg/day or higher, and in mice at the dose levels of 140 mg/kg/day or higher (NTP TR 523 (2007)). Likewise, in the 2-year dermal application study in rats, severe neurological signs frequently observed at 40 mg/kg/day included ataxia, excitability, impaired gait, hypomyotonia, abnormal breathing, lethargy, vocalization and convulsion (NTP TR 523 (2007)). As for the principal pathological findings of the brain included neuronal necrosis, hemorrhage, and/or fibrinoid arteriole necrosis (NTP TR 523 (2007)). The occurrence dose of 40 mg/kg/day was equivalent to Category 2 of the guidance values, and therefore, the substance was classified as Category 2 (central nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information