GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Propylene glycol monoethyl ether
CAS：52125-53-8
Result：
| ID: | 22A4124 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 38.5 degC (closed-cup) (Kyowa Hakko Chemical Co., Ltd. (2007)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its autoignition temperature is 238 degC (Kyowa Hakko Chemical Co., Ltd. (2007)), it is considered that the substance does not ignite at room temperature. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data were available. As relevant information, the LD50 value of > 5000 mg/kg bw for 1-ethoxy-2-propanol (CAS: 1569-02-4) was reported (ECETOC TR 95 (2005)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data were available. As relevant information, the LD50 value of > 8082 mg/kg bw for 1-ethoxy-2-propanol (CAS: 1569-02-4) was reported (ECETOC TR 95 (2005)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Based on the rat LC50 value of more than 42.6 mg/L (4 hours) (PATTY, 5th (2001)), the substance was classified as "Not classified". Since the saturated vapor pressure concentration at room temperature was 14 mg/L, the criterion values for dust/mist were adopted. (> 43 mg/L for 1-ethoxy-2-propanol were reported (ECETOC TR 95 (2005)). |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data were available. As relevant notes, in the rabbit test, application of 1-Ethoxy-2-propanol (CAS: 1569-02-4) caused slight irritation (ECETOC TR 95 (2005)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data were available. As relevant notes, in the rabbit test, instillation of 1-Ethoxy-2-propanol (CAS: 1569-02-4) caused irritation of the conjunctiva and corneal effects, but symptoms were not severe and reversible within 7 days (ECETOC TR 95 (2005)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data were available. As relevant information, for 1-ethoxy-2-propanol (CAS: 1569-02-4), no in vivo data were available, and as for in vitro studies, negative results in the Ames test and in the chromosome aberration test were reported (PATTY, 5th (2001)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data were available. As relevant information, in the inhalation exposure study with 1-ethoxy-2-propanol (CAS No. 1569-02-4) applied to pregnant rats or pregnant rabbits during the organogenetic period, no adverse effects of exposure on offspring were detected at the doses that caused decreased body weight gain in parental animals (PATTY, 5th (2001)). |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the information describing that the rats exposed by inhalation for 4 hours revealed the narcotic influence (PATTY, 5th (2001)), the substance was classified as Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No effects were detected in rats exposed to 100 ppm/6hrs (as vapor, 0.42 mg/L/6hrs) (outside of the range of the guidance values for Category 2) for 13 weeks (PATTY, 5th (2001)). Therefore, "Not classified" category was applicable for inhalation route, but the classification was concluded as "Classification not possible" due to no available data for the other routes. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |