Chemical Name：Boron trifluoride diethyl ether; Boron trifluoride ether complex
CAS：109-63-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Since its flash point reported 59 degC (closed-cup) (GESTIS (Access on Oct. 2010)) is >= 23 degC and <= 60 degC, the substance is classified into Category 3. In addition, it is rated as Subsidiary risks Class 3, by the UNRTDG (UN2604).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Since its autoignition temperature is 185 degC (BUA 261 (2005)), it is considered that the substance does not ignite at room temperature.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	-	-	-	-	The substance contains the metalloid (boron) and it produces the combustible vapor in reaction with water (Sax (11th, 2004)). Since no data is available, classification is not possible.
13	Oxidizing liquids	Not classified	-	-	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen. Since it is rated as Class 8, PkGI, and Subsidiary risks Class 3 (flammable liquid) by the UNRTDG (UN2604), the substance does not correspond to oxidizing liquid.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data were available. It is considered that the substance is immediately hydrolyzed into ethyl ether (vapor) and boron trifluoride (gas) by moisture in the air. (Merck, 14th (2006), Sax, 11th (2004)). As for the current classification of ethyl ether (liquid) (ID666), it was reported as follows; "Since the lowest rat LD50 value of 1207 mg/kg among 1215 to 2450 mg/kg (DFGOT vol.13 (1999)) and 1207 to 1704 mg/kg (PATTY, 5th (2005)) was adopted for the basis of classification, the substance was classified as Category 4." [Refer also to the classification results of ethyl ether (ID 666) and boron trifluoride (ID 584).]
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 1B		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	In the rabbit skin irritation test (patch test, exposure time: 1, 5, or 15 minutes or 20 hours, 4 animal/group), necrosis occurred in parts in the 5-minute application group after 24 hours of application. In the 15-minute and 20-hour groups, necrosis extended to the muscle after 24 hours of application (BUA 261 (2005)). Therefore, the substance was classified as Category 1B.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	The substance was classified as Category 1 since the substance was corrosive to the skin. As relevant notes, in the eye irritation test using rabbits (50 microL, instilled into the conjunctiva sac of the one-sided eye of 4 rabbits), nictitating membrane and conjunctiva partly whitened, partly reddened and swollen at 8 days of observation. The cornea was opaque and the iris inflamed. And exophthalmos and partly necrosis of palpebral rims were noted (BUA 261 (2005)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test using bacteria (OECD 471) were reported (BUA 261 (2005)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether (liquid), it was reported as follows: "Although maternal toxicity was not described, fetal absorption was observed in rats (IUCLID (2005)), embryonic cleft palates increased in rats (DFGOT vol.13 (1999)), fetal head length decreased in mice (DFGOT vol.13 (1999)), and fetal external, internal and skeletal anomalies were observed in rats and mice (DFGOT vol.13 (1999)). Based on the information, the substance was classified as Category 2."
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether, it was reported as follows: "There was no description of toxic symptom in animal tests. There was the respiratory irritation in the case of using it as anesthetics to humans (DFGOT vol.13 (1999), PATTY, 5th (2005), IUCLID (2005)). So it was classified as Category 3 (anesthetic action, respiratory irritation)."　As for the current classification for trifluoroborane (boron trifluoride), it was described as follows. "Based on the descriptions that respiratory irritant, corrosion of the respiratory tract, and pulmonary obstacle (the congestion of lung, pulmonary edemas, pneumonia) were seen in humans (ICSC (J) (1993), HSDB (2005), RTECS (2005)), it was classified as Category 2 (respiratory systems). It was classified as Category 2 (cardiovascular system) based on the description that the cardiovascular system disorders (cardiomyopathy, circulatory shock) were seen in humans (HSDB (2005)). Based on the description that the effect of the nervous system (hyporeflexia, drowsiness, syncope, decreased blood-pressure, hyperpnea, and depression of respiration) were seen in humans (ICSC (J) (1993), HSDB (2005)), the substance was classified as Category 3 (anesthetic action)."
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether (liquid), the classification was described as "Not classified". As for the current classification for trifluoroborane, it was described as follows: "Nephrotoxicity, pneumonia, and stimulation of respiratory organs were reported in rats at the dose levels corresponding to Category 1 of the guidance values (50 ppm/6hrs/day) (ACGIH (2001)). Nephrotoxicity, hemorrhage of nasal mucosa/gum, decreased lung function, osteosclerosis, bone fragility, enamel dissolution and fluorosis were reported in humans (ICSC (J), (1993), IUCLID (2000), HSDB (2005)). It was classified as Category 1 (kidney, respiratory system) and Category 2 (bones, tooth) based on these statements."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.