GHS Classification Result

Chemical Name：Octane-1-thiol; n-Octyl mercaptan
CAS：111-88-6

Result：
ID: 22A4141
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point reported 68 degC (closed-cup) (GESTIS (Access on August 2010)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 240 degC (GESTIS (Access on August 2010)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no fluorine, chlorine or oxygen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the data which were chosen from the various LD50 values for rats documented in the "List 1"information source designated in the GHS classification guidance for the Japanese government, namely, 2000 mg/kg (male) and 1293 mg/kg bw (female) in the test which was conducted in accordance with OECD test guideline and was reported in the valid information source ("Toxicity Testing reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The rat LD50 value of > 2000 mg/kg bw (PATTY, 5th (2000)) and the rabbit LD50 value of 1686 mg/kg bw (PATTY, 5th (2000)) were reported. Based on the rabbit data as selecting the category of greater hazard, the substance was classified as Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - It was reported that exposure of 508 ppm/4hrs (3.04 mg/L/4hrs) to rats caused no mortality and the LDLo was > 5.08 mg/L/4hrs (PATTY, 5th (2001)). Since the value did not provide the basis for the classification, the classification was not possible. Because the test concentration was between the saturated vapor pressure concentration and 90% of it, the test substance was estimated as "vapor mixed with mists" and the criterion values for vapor were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "slight irritant" with the irritation index of 0.3 resulted from the rabbit test (PATTY, 5th (2001)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2 based on the documented case of "moderate or slight irritation" resulted from the rabbit test (PATTY, 5th (2001)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In the guinea pig test, moderate skin sensitization was reported (PATTY, 5th (2001)). However, details on test methods and positive rate were lacking, and thus, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and in the chromosome aberration test using CHL cells were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), as the influence on reproductive function of parental animals, extension of average days of the estrous cycle and low delivery index was observed in females of the 250 mg/kg group. However, no treatment related changes in the indices of sexual functions and fertility of parental animals, and in the development and viability of offspring ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). In addition, about slight extension of estrous cycle, the possibility of the secondary change according to the deterioration of the general status of maternal animals by repeated dose was considered to be the cause. Moreover, the delivery index of 85.85% at 250 mg/kg group was slightly lower than the lower bound (86.74%) of the historical data, and thus, it was guessed to be slight as the influence on reproductive function for maternal animals ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). From the above-mentioned, neither was assumed to be the basis for classification. Therefore, this substance did not induce effects on sexual functions and fertility. However, the effects on development of offspring containing teratogenicity was unknown due to no information available. Therefore, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (central nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In the acute oral toxicity study in rats, deaths occurred at 1000 mg/kg or more, and clinical signs of toxicity such as decrease in locomotor activity, ataxic or abnormal gait, lateral or ventral position, crouching position, lacrimation or chromodacryorrhea, etc. at 1000 mg/kg or higher, and anemia-like symptoms, hypothermia, tremors, hyperirritability and salivation at 2000 mg/kg were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). In addition to these signs, the substance influenced on central nervous system, and it was described that exposure at high levels may result in lowering of consciousness (HSDB (2006)). Thus, the substance was classified as Category 2 (central nervous system). Furthermore, in another acute oral study in rats (LD50 value: 2000 - 2445 mg/kg), clinical signs of lethargy and narcosis were described (PATTY, 5th (2001)). Category 3 (narcotic effects) were, thereby, added. In addition, digestive tract injuries such as erosions and ulcers of the forestomach were reported. However, these findings were excluded from the basis for classification since it was described that those were considered as changes indicating irritating effects on mucous membrane ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)).
9 Specific target organ toxicity - Repeated exposure Category 2 (hematopoietic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422), the principal findings observed at 250 mg/kg/day (converted dose level as that of 90-day study: 97.2 - 117 mg/kg/day) were as follows: decrease in locomotor activity, abnormal gait, suppression of body weight gain in systemic general conditions, low values of erythrocyte count and hemoglobin concentration in hematology, high values of GPT and total bilirubin and low value of triglyceride in clinical chemistry, dark reddish discoloration and enlargement of the spleen, and thickening of forestomach wall in necropsy. Histopathologically, treatment-related changes were observed in the spleen and femoral bone marrow at 250 mg/kg/day, and in the stomach at 50 mg/kg/day or higher. The former included increased erythropoiesis and hemosiderin deposition. The latter consisted of hyperplasia, hyperkeratosis, submucosal edema or inflammatory cellular infiltrations in the squamous epithelium of the forestomach which was attributed to irritability of the test article ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). As stated above, the effects on blood system, spleen and bone marrow appeared, and enhancement of erythropoiesis and increased hemosiderin deposition were noted in the doses equivalent to Category 2 (97.2 - 117 mg/kg/day) of the guidance values ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)). Consequently, the substance was classified as Category 2 (hematopoietic system). Besides, the changes in the forestomach observed at 50 mg/kg/day (converted dose level as that of 90-day study: 19.4 - 23.3 mg/kg/day) or more were excluded from the basis for classification because of the judgment as an irritating effect by repeated oral administration with the substance ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council), (Access on Aug. 2010)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 72h-EC50 = 0.014 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and there are no adequate data on rapid degradation.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information