Chemical Name:3,3'-Thiodipropionic acid
CAS:111-17-1
ID: | 22A4161 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2010 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains oxygen which is chemically bonded only carbon or hydrogen. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 values of > 2000 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)) and 3000 mg/kg (JECFA FAS 51 (1974)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Category 1 | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 based on the physicochemical property of pH 2.0 (saturated aqueous solution at 20 degree centigrade) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
The substance was classified as Category 1 based on the physicochemical property of pH 2.0 (saturated aqueous solution at 20 degree centigrade) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and in the chromosome aberration test using CHL/IU cells were reported ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council), Access on Aug. 2010)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | It was reported that no adverse effects were observed in the growth rate, mortality and pathological examination in the 2-year dietary administration study in rats with the concentrations of 0.3 - 3% of this substance (JECFA FAS51 (1974)). However, since only this information mentioned was insufficient to be the basis for classification, the classification was not possible. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the reproductive toxicity screening test (OECD TG421) in rats by oral administration from 2 weeks before mating to post-delivery day 3, treatment-related death was found at high dose (1,000 mg/kg). Abnormal findings in the histopathological examination such as atrophy of seminiferous tubule in the testis were observed in males of the 300 mg/kg group, thus, treatment-related effect on fertility was suggested from these findings. However, there were no treatment-related adverse effects on the mean duration of estrus cycle and copulation. All dams delivered normally, and reproduction indices such as the pregnancy, delivery and the birth revealed no treatment-related influence. And, there were no treatment-related effects on the viability of offspring, state of the offspring at post delivery day 0 and day 4 ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). Therefore, no effects on sexual functions and fertility of parental animals were observed. However, since data on the development of the offspring were insufficient, the substance was classified as "Classification not possible". |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | In the acute oral toxicity study in rats administered at the dose of 2000 mg/kg, no deaths occurred and no test substance related effects were noted in observations of general conditions, body weight measurements and necropsy ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). Based on the results, classification was equivalent to "Not classified" for oral route. the classification for specific target organ toxicity (single exposure) was determined as "Classification not possible" because the effects for other routes were unknown due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data were available. As relevant information, in the 28-day repeated dose oral toxicity study in rats, it was reported that the NOAEL was 200 mg/kg/day (converted dose level as that of 90-day study: 62.2 mg/kg/day) based on the results that possible treatment-related changes were observed in clinical signs and in stomach of both sexes at 1000 mg/kg/day (converted dose level as that of 90-day study: 311 mg/kg/day) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Aug. 2010)). However, the results were unable to use for classification because the effects at near the upper limit dose of the guidance values (100 mg/kg/day) were unknown. Additionally, no obvious toxic effects on growth rate, mortality rate and histopathological examination were noted by 2-year dietary administration to rats at the concentrations of 0.3 - 3% (JECFA FAS 51 (1974)), but details were unknown due to no further information. |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3 from its 72h-ErC50 = 50 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Classified as "Not classified" since it is judged to be rapidly degradable (Readily biodegradable, BOD degradation rate: 47, 94, 93% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1997)) though the acute toxicity is Category 3. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |