GHS Classification Result

Chemical Name：Dimethyl maleate
CAS：624-48-6

Result：
ID: 22A4170
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point reported 95 degC (closed-cup) (IUCLID (2000)) is over 93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (unsaturated bonds) associated with self-reactive properties in the molecule, but classification is not possible due to lack of additional data.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 390 degC (IUCLID (2000)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 1.41 mL/kg (= 1635 mg/kg) (PATTY, 5th (2001)), the substance was classified as Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 value of 0.53 mL/kg (= 610 mg/kg) (PATTY, 5th (2001)), the substance was classified as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In the rabbit test, only slight erythema and edema were observed (PATTY, 5th (2001)). In other rabbit test (OECD TG 404), no irritating effect was reported (IUCLID (2000)). Based on these documents, the substance was classified as "Not classified" in the JIS classification (Category 3 in the UN-GHS classification). As relevant notes, irritating effects were reported in other rabbit test in 24-hour application (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The substance was classified as Category 2B based on the documented case of "slightly irritating" resulted from the rabbit test (OECD TG 405) (IUCLID (2000)). In other rabbit tests, highly irritating, or mild irritating were reported (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In the guinea pig maximization test (OECD TG 406, GLP-compliant), erythema and edema were observed in all of the treated animals, but the irritating effect was not observed in the control group after 48 and 72 hours of elicitation. Positive rate was 100% (10/10) in the treated group and 0% (5/5) in the control group, and clear sensitizing potential was reported (IUCLID (2000), original literature: Food Chem Toxicol Vol. 29 (1991)). Based on the information, the substance was classified as Category 1.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test using erythrocytes of mice orally administered (in vivo mutagenicity test in somatic cells) (PATTY, 5th (2001)). As relevant information, as for in vitro study, negative results in the Ames test were reported (PATTY, 5th (2001), IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Because the single dermal application of 0.5 or 2 g/kg to rats did not cause deaths or induce any systemic effects (PATTY, 5th (2001)), the classification for dermal route corresponded to "Not classified". However, the classification for specific target organ toxicity (single exposure) was determined as "Classification not possible" due to no available data for the other routes (oral, inhalation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 4-week repeated dermal toxicity study in rats, slight increase in leukocyte count and reduced serum levels of reduced and oxidized glutathione were noted in the high dose group at 500 mg/kg/day (converted dose level as that of 90-day study: 153.8 mg/kg/day) except the local effects of the skin, and no serious toxic effects were seen (PATTY, 5th (2001), IUCLID (2000)). Therefore, the classification for dermal route corresponded to "Not classified". However, the classification for specific target organ toxicity (repeated exposure) was determined as "Classification not possible" due to no available data for the other routes (inhalation, oral).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information