GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Isobutyric anhydride
CAS：97-72-3
Result：
| ID: | 22A4172 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point reported 67 degC (closed-cup) (GESTIS (Access on Sept. 2010)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its autoignition temperature is 329 degC (Hommel (1996)), it is considered that the substance does not ignite at room temperature. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen which is chemically bonded only to carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data were available. As relevant information, the rat LD50 value of > 500 mg/kg was reported (SIDS (J) (Access on Sep. 2010)) for isobutyric acid as the hydrolysate of the substance. [For health hazards, refer also to isobutyric acid (CAS; 79-31-2) as the hydrolysate of the substance.] |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data were available. As relevant information, the rabbit LD50 value of > 200 mg/kg was reported (SIDS (J) (Access on Sep. 2010)) for isobutyric acid as the hydrolysate of the substance. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Although the rat LC50 value of > 5.1 mg/L was reported (SIDS (J) (Access on Sep. 2010)), the value did not provide the basis for the classification, the classification was not possible. Since the test concentration (5.1 mg/L) was lower than 90% of the saturated vapor pressure concentration (42.6 mg/L), the criterion values for gas were adopted. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 1 |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance is rapidly hydrolyzed to isobutyric acid by contact with water (SIDS (J) (Access on Sep. 2010)). Thus, the substance was classified as Category 1 based on the document that open application of isobutyric acid to rabbit skin caused some necrosis within 24 hours (PATTY, 5th (2001)). |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
The substance is rapidly hydrolyzed to isobutyric acid by contact with water (SIDS (J) (Access on Sep. 2010)). Thus, the substance was classified as Category 1 based on the document that instillation of isobutyric acid to rabbit eyes caused severe corneal burning (PATTY, 5th (2001)), and its preexisting classification for skin corrosion/irritation was Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data were available. As relevant information, it was reported that isobutyric acid was negative in the Ames test (SIDS (J) (Access on Sep. 2010)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the clinical sign such as rales (breathing sound) and nasal discharge observed in the acute inhalation study in rats (LC50 > 5.1 mg/L), it was concluded that the substance caused irritating effects to the upper respiratory tract (SIDS (J) (Access on Sep. 2010)). Therefore, the substance was classified as Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data were available. As relevant information, there was a report describing that single inhalation of the substance caused irritation to the upper respiratory tract and repeated exposure might exacerbate the irritating effects (SIDS (J) (Access on Sep. 2010)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
This substance is thought to be rapidly hydrolyzed into isobutyric acid (CAS No. 79-31-2) in water (the half-life in water = 2.407 minutes (pH = 8), 24.067 minutes (pH = 7) (HYDROWIN)). Although there are no data available on isobutyric anhydride, the substance is classified into Category 3 from 72h-EC50 of isobutyric acid = 45 mg/L (39.9 mg/L as isobutyric anhydride) for algae (Scenedesmus subspicatus) (IUCLID, 2000). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | This substance is thought to be rapidly hydrolyzed into isobutyric acid (CAS No. 79-31-2) in water (the half-life in water = 2.407 minutes (pH = 8), 24.067 minutes (pH = 7) (HYDROWIN)). This substance is classified as "Not classified" since isobutyric acid is rapidly degradable (28d-degradation rate tested by OECD TG301C: > 60% (IUCLID, 2000)) and it is estimated not to be bioaccumulative (LogPow = 1.24 (PHYSPROP Database, 2011)) though its acute toxicity is Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |