GHS Classification Result

Chemical Name：Butyric anhydride
CAS：106-31-0

Result：
ID: 22A4174
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point 88 degC (190 degF) (open-cup) was obtained (Merck (14th, 2006)) and it is estimated that the flash point measured by the closed-cup method fall within the range of > 60 degC and <= 93 degC. Based on these information, the substance was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition temperature is 279 degC (535 degF) (HSDB (2002)), it is considered that the substance does not ignite at room temperature.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen which is chemically bonded only carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data were available. As relevant information, the rat LD50 values of 8790, 2940 and 2000 mg/kg bw were reported (all from PATTY, 5th (2001)) for normal butyric acid. [For health hazards, refer also to n-butyric acid (CAS; 107-92-6) as the hydrolysate of the substance.]
1 Acute toxicity （Dermal） Classification not possible - - - - No data were available. As a relevant note, the rabbit LD50 value of 530 mg/kg bw was reported (PATTY, 5th (2001)) for n-butyric acid.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data were available. As a relevant note, it was reported that the exposure of 2.4 mg/L/8hrs (saturated vapor) of n-butyric acid to rats caused no death.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was described in the human case that the substance caused skin irritation by contact with vapor (HSDB (2002)). And as for the information of n-butyric acid it was reported that in the guinea pig test (occlusive application with 10mg for 24 hours, non-occlusive application with 500mg for 24 hours), severe reactions were observed (PATTY, 5th (2001)). And it was also reported that in the rabbit test (OECD TG404, GLP-compliant), corrosive effects were observed (IUCLID (2000)). Based on these documents, the substance was classified as Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		The substance caused eye irritation by contact with vapor in the human case (HSDB (2002)). As for the information of n-butyric acid, it is reported that instillation of aqueous solution more than 5% caused severe corneal burns in the rabbit test (PATTY, 5th (2001)). Based on the documents, the substance was classified as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - The classification was not possible due to lack of data. As relevant information, it was reported that n-butyric acid caused no skin sensitization for human (subcutaneous injection, 2 weeks, the index of sensitization were infiltration of leukocytes or eosinophils) (PATTY, 5th (2001)). Since it was not conducted in accordance with standard protocol, the result was not adopted as the basis of the classification.
5 Germ cell mutagenicity Classification not possible - - - - No data were available. As relevant information, as for in vitro studies, negative results were reported in the Ames test and chromosome aberration test for n-butyric acid (PATTY, 5th (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data were available. As relevant information, as for the information of n-butyric acid, in the oral administration study using pregnant rat during the organogenetic period, maternal mortalities were high, and maternal body weight gain was markedly suppressed, but no effects on progeny were reported (PATTY, 5th (2001)). However, there was no information for reproductive toxicity.
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		No data were available for the substance (anhydrate). It was reported that single exposure to n-butyric acid aerosol to rabbits at the concentration of 40 mg/L/1.5hrs (converted value as that of 4-hour exposure: 15 mg/L/4hrs: over the range of Category 2 of the guidance values) caused signs of bronchitis and emphysema (PATTY, 5th (2001)). It was also reported that another inhalation study in rabbits exposed to the concentration of 0.4 mg/L/1.4hrs (converted value as that of 4-hour exposure: 0.24 mg/L: within the range of Category 1 of guidance value) revealed congestion, edema, atelectasis and emphysema of the lungs (IUCLID (2000)). According to the latter information, Category 1 (lung) was judged as relevant. However, because the information was obtained from the "List 2" information source designated in the GHS classification guidance for the Japanese government, the substance was classified as Category 2 (lung).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data were available for the substance (anhydrate). As relevant information, as for the information of n-butyric acid, it was reported that the suppression of body weight gain, and papillomatosis and hyperkeratosis of gastric tissues were observed in the oral study in rats (feeding study, up to 35 weeks, dose levels were unknown) (PATTY, 5th (2001)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		This substance is thought to be rapidly hydrolyzed into n-butyric acid (CAS No. 107-92-6) in water (the half-life in water = 1.679 minutes (pH = 8), 16.789 minutes (pH = 7) (HYDROWIN)). Although there are no data available on butyric anhydride, the substance is classified into Category 3 from 72h-EC50 of n-butyric acid = 46.7 mg/L (26 mg/L as butyric anhydride) for algae (Scenedesmus subspicatus) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - This substance is thought to be rapidly hydrolyzed into n-butyric acid (CAS No. 107-92-6) in water (the half-life in water = 1.679 minutes (pH = 8), 16.789 minutes (pH = 7) (HYDROWIN)). This substance is classified as "Not classified" since n-butyric acid is rapidly degradable (28d-degradation rate tested by OECD TG301C: > 60% (IUCLID, 2000)) and it is estimated not to be bioaccumulative (LogPow = 1.24 (PHYSPROP Database, 2011)) though its acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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