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GHS Classification Result

Chemical Name：tert-Butyl peroxybenzoate
CAS：614-45-9

Result：


ID:	22A4176
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Classification not possible	-	-	-	-	It contains chemical groups (adjacent oxygen atoms) with explosive properties and it was evaluated as "violent" as organic peroxides by each test to determine the sensitivities of substance to the effect of heat under confinement. However, classification is not possible since test results as explosives were not reported.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Since its flash point reported 66 degC (closed-cup) (Gangolli (2nd, 1999)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Organic peroxide
9	Pyrophoric liquids	Not classified	-	-	-	-	Since its autoignition temperature is 130 degC (Hommel (1996)), it is considered that the substance does not ignite at room temperature.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Classification not possible	-	-	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen. Since no test results are available, classification is not possible.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Type C		Danger	H242: Heating may cause a fire	P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P234: Keep only in original container. P280: Wear protective gloves/protective clothing/eye protection/face protection. P410: Protect from sunlight. P420: Store away from other materials. P501: Dispose of contents/container to ...	The substance is mentioned in 212 page of "UNRTDG Manual of Tests and Criteria (4th Ed. 2003)" as an example of a test report, and classified into Type C. As a result, the substance having concentration of more than 77weight% is classified into Division 5.2 (UN3103: Type C) in United Nations Recommendations on the Transport of Dangerous Goods.
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 value of 3639 - 4838 mg/kg (PATTY, 5th (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 value of 3817 mg/kg (PATTY, 5th (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Insufficient data were available. The rat LC50 value of > 0.26 mg/L was reported (PATTY, 5th (2001)). Since the value did not provide the basis for the classification, the classification was not possible. According to the description of the maximum attainable vapor concentration, it was considered the test was carried out at the saturated vapor pressure concentration.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Not classified	-	-	-	-	No irritation was reported in the rat test, although details were unclear (PATTY, 5th (2001)). And in the datum from the "List 3" information source designated in the GHS classification guidance for the Japanese government, mild irritation was reported in the standard Draize test (RTECS (2008), original literature: Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia.: -, 545 (1994)). Based on these documents, the substance was classified as "Not classified" in the JIS classification (Category 3 or "Not classified" in the UN-GHS classification).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Slight irritation was reported in the rabbit test, although details were unclear (PATTY, 5th (2001)). And in the datum from the "List 3" information source designated in the GHS classification guidance for the Japanese government, it was reported that instillation of 100 mg of test substance for 1 minute to rabbit eyes caused mild irritation (RTECS (2008), original literature: Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.: 8, 25, (1958)). Based on these documents, the substance was classified as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	Insufficient data were available. As for the information about skin sensitization study, although no details of test methods were provided, the substance was reported as "not an irritant" (PATTY, 5th (2001)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	The classification was concluded as "Not classified" based on the negative results in the micronucleus test using peripheral blood obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (NTP DB (Access on Sep. 2010)). As relevant information, as for in vitro studies, positive results were reported in the Ames test and in the chromosome aberration test using Chinese hamster ovary cells (NTP DB (Access on Sep. 2010)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data were available. As relevant information, it was reported that no adverse effects were observed in rats exposed at saturated vapor pressure concentration of 0.26 mg/L (PATTY (5th, 2001)). However, the test concentration was within the range of the guidance values, the classification was not possible.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In the 13-week repeated dose oral toxicity studies in rats and mice (dose range: 30 - 500 mg/kg/day), the toxic effects attributed to substance were limited to the lesions of the forestomach in both species which consisted of dose-dependent increases in forestomach weight and hyperplasia of squamous epithelium in most of the animals administered (NTP TOX 15 (1992)). However, the forestomach lesions were considered to be local effects (site of contact) caused by oral gavage of the test substance (NTP TOX 15 (1992)), and thereby not evidenced to classify. Since no systemic effects were found up to the doses over the guidance values, the classification was equivalent to "Not classified" for oral route. The classification for specific target organ toxicity (repeated exposure) was, however, concluded as "Classification not possible" due to no data available and unknown effects for the other routes.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）