GHS Classification Result

Chemical Name：o-Aminophenol
CAS：95-55-6

Result：
ID: 22A4179
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available. As relevant notes, it is classified into Division 6.1 (UN2512) (UNRTDG).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is 190 degC (ICSC (2005)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 1300 mg/kg (Journal of The American College of Toxicology. vol 7, p 279-333 (1988)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In the rabbit tests (compliant with test methods of French cosmetics, AFNOR, and OECD), occlusive or semi-occlusive application of 0.5 g of test substance caused no irritation and primary skin irritation index value was 0 (maximum value was 8) (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)). Based on the document, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In the rabbit test (complied with main requirements in test methods of French authorities, AFNOR, and OECD), instillation of 100 mg of the substance to conjunctival sac caused slight irritation, and irritation index (AOI) was under 15 (9.83/110) after 24 hours (IUCLID (2000)). Based on the document, the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data were available. As relevant notes, it was reported that the substance might cause bronchial asthma (HSDB (2003)).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 based on the document that the substance was included in hair dye and contact dermatitis was caused to the hairdressers and consumers and listed as a sensitizer (Contact Dermatitis, Frosch, 4th (2006)). As relevant information, in the guinea pig maximization test, p-phenylenediamine induced cross sensitivity in 4/10 guinea pigs (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The classification was concluded as Category 2 based on the positive results in the micronucleus test using bone marrow obtained from mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)). As relevant information, negative results in the sister chromatid exchange test using bone marrow obtained from hamsters intraperitoneally administered (in vivo genotoxicity test in somatic cells) were reported (Journal of The American College of Toxicology. vol.7, p 279-333 (1988)). As for in vitro studies, positive results in the Ames test (NTP DB (Access on Sep. 2010)), the sister chromatid exchange test using human fibroblast cells, human lymphocytes and Chinese hamster cells (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)) were reported.
6 Carcinogenicity Classification not possible - - - - Insufficient data were available. As relevant information, in the 105-week dermal study in rats with hair dye containing this substance of 0.3%, no carcinogenicity was found (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988). In the 21 to 23-week dermal study in mice with hair dye containing this substance of 0.3%, no significant differences between the test substance dosing groups and the non-treated group were found for the incidences of neoplastic and non-neoplastic lesions (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)).
7 Reproductive toxicity Classification not possible - - - - In the two-generation dermal study in rats with hair dye formulations containing 0.3% of this substance at 0.5 mL, no treatment-related signs of toxicity were observed in any generations, and the treated parents were comparable to controls in fertility, gestation, viability and livebirth of offspring and nurse indices (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)). However, since this study was dermal administration study and data on the development of the offspring were insufficient, the substance was classified as "Classification not possible". As relevant information, it was reported that intraperitoneal injection of 100 - 200 mg/kg of this substance into pregnant hamsters on day 8 of gestation produced significant increases in the incidence of neural tube defect (exencephaly, encephalocele, spinal bifida) and anomalies of the eyes and skeleton, however, general toxicity of the maternal animal was not seen (Journal of The American College of Toxicology. vol. 7, p 279-333 (1988)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral toxicity study in rats (LD50 value: 1300 mg/kg), it was reported that excitement was noted within 20 - 30 minutes after administration, and listlessness and loss of reflex to external stimuli were observed. The methemoglobin concentration was less than 10%, and deaths occurred within 1 - 48 hrs after administration (Journal of The American College of Toxicology, vol. 7, p 279-333 (1988)). As described above, the dose of 1300 mg/kg (=LD50 value) was equivalent to Category 2 of the guidance values, and based on the clinical signs after administration, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There was the description that excess exposure to o-aminophenol by inhalation might occur methemoglobinemia (PATTY, 5th (2001)). Moreover, it was described that aminophenol caused reduction of oxygen transport ability (methemoglobinemia) (SITTIG, 5th (2008)). In addition to the information, decreased erythrocyte count and increased methemoglobin concentration were observed as the changes in the peripheral blood in the oral dose toxicity study in rats administered at 130 mg/kg/day (converted dose level as that of 90-day study: 43.3 mg/kg/day, equivalent to Category 2 of the guidance values) for one month (Journal of The American College of Toxicology, vol. 7, p 279-333 (1988)). Based on these documents, the substance was classified as Category 2 (blood).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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