GHS Classification Result

Chemical Name：3-Cyanopyridine
CAS：100-54-9

Result：
ID: 22A4189
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is > 600 degC (IUCLID (2000)) Original literature: Degussa Antwerpen N.V. Antwerpen, Chemical Risk Information Platform (CHRIP) (Access on Sept. 2010) Original literature: ACROS MSDS), it is considered that the substance does not presumably ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - The substance is a solid and its melting point is less than 55 degC, but classification is not possible due to lack of additional data.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 values of 1475 mg/kg (male) and 1455 mg/kg (female) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LDLo value of 2 g/kg (RTECS (2010), original literature: U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Pyridine and Pyridine Derivatives Category (2003)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "non-irritation" in the rabbit test (OECD TG 404) (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified as Category 2A based on the documented case of "highly irritating" in the rabbit test (OECD TG 405) (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro studies, negative results in the Ames test and the chromosome aberration test using CHL cells were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, testis) Warning H371: May cause damage to organs (nervous system, testis) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral study in rats (OECD TG 401, GLP-compliant), deaths occurred at the doses over 1297 mg/kg - 1388 mg/kg, and clinical signs observed after administration at doses of 1006 mg/kg or more in both sexes included hypoactivity, bradypnea, salivation, lacrimation, wheezing, ataxic gait, and additionally tremors, wryneck and exophthalmos were less frequently observed. In the decedents of the study, prone position, lateral position, hypothermia, abdominal breathing, mydriasis and clonic convulsion were reported ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council)) (Access on Sep. 2010)). As for the information from the "List 2" information source designated in the GHS classification guidance for the Japanese government, it was reported that symptoms of the central nervous system were observed after inhalation exposure of 6 to 12 ppm in humans (HSDB (2002)). The dose levels in which clinical signs occurred in the acute oral study in rats as described above were ranged within Category 2 of the guidance values, and thereby the substance was classified as Category 2 (nervous system). Furthermore, in the acute oral study in rats as described above, macroscopically small size of the testes, and giant cell formation, decreased number of seminiferous epithelial cells and vacuolation of Sertoli cells in the histopathology were observed in survivors at doses of 1485 mg/kg/day or higher. It was reported that the test substance was considered to have testicular toxicity ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)). Based on the information, the substance was classified as Category 2 (testis).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 28-day repeated dose oral toxicity study in rats (Japanese test guideline, GLP-compliant), increase in leukocyte count, reticulocyte count, MCV value and MCH value, and decrease in erythrocyte count were found in hematology at the dose of 180 mg/kg/day (converted dose level as that of 90-day study: 56 mg/kg/day, equivalent to Category 2 of the guidance values). And histologically extramedullary hematopoiesis and deposition of hemosiderin in the red pulp of the spleen, which caused by the acceleration of destruction of erythrocytes were observed at 180 mg/kg/day in both sexes ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)). Consequently, the substance was classified as Category 2 (blood). Furthermore, necrosis of spermatocytes and spermatids, decreased number of spermatids and vacuolation of Sertoli cells were observed in the testes of 180 mg/kg/day group ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)). Based on the findings, the substance was classified as Category 2 (testis). In addition, as histopathological findings, centrilobular hypertrophy of hepatocytes of the liver and hyaline droplets in the proximal tubular epithelium of the kidneys were found at doses of 30 mg/kg/day or higher ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)). However, because there were no histological alterations suggesting functional impairment of the liver, and the change in the kidneys was reported as male-rat-specific spontaneous change ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Sep. 2010)), those findings were not evidenced to classify.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information