GHS Classification Result

Chemical Name:Triallyl cyanurate
CAS:101-37-1

Result:
ID: 22A4191
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (unsaturated bonds associated with self-reactive properties in the molecule, but classification is not possible due to lack of additional data.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - The substance is a solid and its melting point is less than 55 degC, but classification is not possible due to lack of additional data.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 values of 753 mg/kg and 590 mg/kg (BUA 248 (2003)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Based on the description that 2000 mg/kg administration to rats caused no mortality and the rat LD50 value was > 2000 mg/kg (OECD TG 402, GLP-compliant) (BUA 248 (2003)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - The rat LC50 value of > 0.333 mg/L/1h = 0.17 mg/L/4hrs was reported (BUA 248 (2003)). Since the value did not provide the basis for classification, the substance was classified as "Classification not possible". According to the description of "saturated vapor" in the original text, the criterion values for vapor were adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" based on the document that primary skin irritation index value was 0 and resulted as non irritant in the rabbit test (OECD TG 404) (BUA 248 (2003)).
3 Serious eye damage/eye irritation Not classified - - - - The substance was classified as "Not classified" based on the document that primary skin irritation index value was 1/110 and resulted as non irritant in the rabbit test (OECD TG 405) (BUA 248 (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In the guinea pig maximization test (OECD TG 406, GLP-compliant), one of ten animals exhibited only slight erythema of the skin and positive rate was 10%, which resulted as non sensitizing (BUA 248 (2003)). However, it was the datum from the "List 2"information source designated in the GHS classification guidance for the Japanese government, and original publication were not available. Therefore, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (BUA 248 (2003)). As relevant information, as for in vitro studies, negative results were reported in the Ames test, the HGPRT gene mutation test using V79 cells and the chromosome aberration test using human peripheral lymphocytes (BUA 248 (2003)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the acute oral toxicity study in rats at the dose levels of 353 - 1116 mg/kg (LD50 value: 353 mg/kg), the following symptoms such as disturbance of motor coordination, decrease in muscle tonus, lateral position, tremors and clonic convulsion, etc. were reported as clinical signs after administration (BUA 248 (2003)). The test doses were ranged within Category 2 of the guidance values, and there was statement describing that the effects after single administration were mainly on the central nervous system apart from unspecific toxic symptoms (BUA 248 (2003)). Based on the information, the substance was classified as Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the 28-day repeated dose oral toxicity study in rats (OECD TG407, GLP-compliant), neuronal dysfunction, coordination disturbances, decreased muscle tonus, loss of righting reflexes were observed at 56.2 mg/kg/day, some animals exhibited clonic convulsion. In addition, the following changes were observed at 178/215 mg/kg/day: significantly increased ALT, decreased albumin, and increased liver weights accompanied histopathologically by hepatocellular single cell necrosis with mononuclear inflammatory reaction (BUA 248 (2003)). Based on the information, it was reported that the target organs were considered to be the central nervous system and the liver (BUA 248 (2003)). The effects appeared at 56.2 mg/kg/day (converted dose level as that of 90-day study: 17.5 mg/kg/day) for the central nervous system and at 178/215 mg/kg/day (converted dose level as that of 90-day study: 55.4/66.9 mg/kg/day) for the liver, and these were equivalent to Category 2 of the guidance values. Therefore, the substance was classified as Category 2 (central nervous system, liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information