GHS Classification Result

Chemical Name:Triethylenediamine
CAS:280-57-9

Result:
ID: 22A4192
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition temperature is 350 degC (GESTIS (Access on Oct. 2010)), it is considered that the substance does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Among four data of the rat LD50 values (700, 1070, 1870 and 2260 mg/kg bw) (SIDS (2005)), three data corresponded to Category 4, and the other one corresponded to "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). The substance was classified as Category 4, having the greatest number of data.
1 Acute toxicity (Dermal) Not classified - - - - Based on the report that the rabbit LD50 value was > 3200 mg/kg bw (SIDS (2005)) and no death was observed, the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Exposure at the saturated vapor pressure concentration (4.48 mL/L) /8hrs (converted value as that of 4-hour exposure: 8.96 mL/L) to rats caused no mortality (LC50: > 8.96 mL/L/4hrs) (SIDS (2005)). And in another study in rats, exposure at 20.2 mL/L/1h (converted value as that of 4-hour exposure: 5.05 mL/L) caused no mortality (LC50: > 5.05 mL/L/4hrs) (SIDS (2005)). Both test concentrations corresponded to "Not classified". The test concentration was higher than the saturated vapor pressure concentration (4.48 mL/L), the criterion values for dust/mist were adopted.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
The substance was classified as Category 2 based on the document that the primary dermal irritation index (PDII) was 4.05 in the rabbit Draize test (SIDS (2005)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
The substance was classified as Category 2 based on the document that PIS (primary irritation score) was 7.1/13 in the rabbit test (OECD TG 405, GLP-compliant) (SIDS (2005)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified as "Not classified" based on the document that non sensitization were reported in two guinea pig maximization tests (OECD TG 406, GLP-compliant) (SIDS(2005)).
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the mouse micronucleus test (in vivo mutagenicity test) (SIDS (2005)). As relevant information, as for in vitro study, negative results in the Ames test were reported (SIDS (2005)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the combined repeated dose oral toxicity study with the reproduction/developmental toxicity study in rats (OECD TG 422, GLP-compliant), increased resorption, decreased live litter size, decreased postnatal pup survival and decreased pup body weights were observed in the high dose group that cause significant general toxicity in male and female parental animals (SIDS (2005)). Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the acute oral toxicity study in rats, administration at the dose levels of 1000 - 1500 mg/kg (equivalent to Category 2 of the guidance values) caused hypoactivity and ruffled coat, and the rats became semi-comatose to comatose within two hours, then some died and the remaining animals returned to normal within one to three hours. Gross necropsy revealed nothing remarkable (SIDS (2005)). Based on the information, the substance was classified as Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (upper respiratory tract) Danger H372: Cause damage to organs through prolonged or repeated exposure (upper respiratory tract) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the inhalation study in rats exposed for 6 hours/day, 5 days/week for 4 weeks (OECD TG 412, GLP-compliant), minimal to moderate chronic laryngitis was noted in the analytical dose levels of 0.06 and 0.41 mg/L, corresponding to Category 1 of the guidance values (converted values as that of 90-day study: 0.02 and 0.14 mg/L) (SIDS (2005)). Based on the information, the substance was classified as Category 1 (upper respiratory system). In addition, severe acute necrotizing laryngitis was observed in the dead females. In the combined repeated dose oral toxicity study with the reproduction/developmental toxicity screening test in rats for 28 days (OECD TG 422, 2 studies in compliance with GLP), the effects on the kidneys (inflammatory and/or proliferative lesions, acute pyelitis) or on the urinary bladder were found at the dose over the range of Category 2 (1000 mg/kg/day, converted dose level as that of 90-day study: 333 mg/kg/day) (SIDS (2005)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Classified as "Not classified" from its 96h-LC50 = 1,730 mg/L for fish (Pimephales promelas) (AQUIRE, 2011).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 450 mg/L (PHYSPROP Database, 2011)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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