GHS Classification Result

Chemical Name：Chloroacetamide
CAS：79-07-2

Result：
ID: 22A4197
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen and chlorine (but not fluorine) which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 value of 138 mg/kg (BUA Report 225 (2000)), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In the rabbit test (OECD TG 404), 4-hour application of 500 mg of the substance as paste form with saline solution to 3 rabbits caused mild erythema and edema in one animal, moderate erythema and edema in the second one, and severe erythema and edema in the third one 1 hour to 3 days after patch removal. All signs of irritation were reversible 7 days after removal of the patch, and authors evaluated the substance as slightly irritating (BUA Report 225 (2000)). The substance was classified as Category 2 based on the document that two of three animals exhibited more than moderate irritation 1 hour to 3 days after patch removal.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In the rabbit eye irritation test (OECD TG 405), instillation of 100 mg of the substance to conjunctival sac caused severe reddening and swelling of conjunctiva and corneal opacity 1 to 7 hours after application. The disappearance of these effects were very slow but were reversible after 21 days, and authors evaluated the substance as irritating to eyes (BUA Report 225 (2000)). Based on the information, the substance was classified as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In humans, there were many case reports of occurrence of allergic contact dermatitis and positive results in the patch tests with both patient and healthy volunteers (BUA Report 225 (2000), HSDB (2006)). In the guinea pig maximization test, 60 - 80% of treated animals showed positive response after the initial challenge. At rechallenge, 80% of the animals showed positive reaction, and the authors concluded that the substance had strong sensitizing potential (BUA Report 225 (2000)). This substance is used as preservative in cutting oil, paints, adhesives and for leather. A contact dermatitis may be caused in hairdressers and shoes manufacturers, and the substance was listed as a skin sensitizer (Contact Dermatitis, Frosch, 4th (2006)). Based on these documents, the substance was classified as Category 1.
5 Germ cell mutagenicity Not classified - - - - The classification was concluded as "Not classified" based on the negative results in the dominant lethal test using mice intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells), the chromosome aberration test using spermatogonia and bone marrow cells of Chinese hamster orally administered (in vivo mutagenicity test in germ cells), and the micronucleus test using bone marrow of mice orally administered (in vivo mutagenicity test in somatic cells) (BUA Report 225 (2000)). As relevant information, as for in vitro study, negative results were reported in the Ames test (BUA Report 225 (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the study that 50 mg/kg of the substance was subcutaneously administered to the rats of 2 strains (CD and BDIX) on days 13 or 14 of gestation, no developmental effects of prenatal fetus were observed, postnatal deaths were observed in about half of the pups in both strains (BUA Report 225 (2000)). In addition, the EU classification for the substance was "GHS Repro cat. 2". Therefore, the substance was classified as Category 2. As relevant information, in the study that 20 mg/kg of the substance was intraperitoneally administered to the rats on day 7 or 11 and 12 of gestation, no effects on the fetus were observed (BUA Report 225 (2000)). In addition, the substance was prohibited from using in Canada in 2009, the evaluation was necessary when placing it back on the market.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In two 3-month feeding studies in rats, significant reduction in testicular weight and dysfunction of spermatogenesis was reported at the highest dose level of 50 mg/kg/day (BUA Report 225 (2000)). However, testicular effect was treated as adverse in the classification for reproductive toxicity, therefore it was not object of this hazard class. As for the other effects, there were no reports describing adverse effects. The effects at the upper limit of the guidance values (100 mg/kg/day) or higher were unknown. Furthermore, in the 30-day dermal application study in rabbits, fatty infiltration of the liver and heart, and deposition of hemosiderin in the spleen were reported at the dose level of 100 mg/kg/day (converted dose level as that of 90-day study: 33.3 mg/kg/day) or higher (BUA Report 225 (2000)). However, since no effects were seen in hematology and no details for the degree and toxicological significance of the histopathological changes were known, "Classification not possible" was concluded.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-EC50 = 14 mg/L for crustacea (Daphnia magna) (BUA 225, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified as "Not classified" since it is rapidly degradable (BIOWIN) and its bioaccumulation potential is estimated to be low (Log Kow = -0.53 (PHYSPROP Database, 2011)) though its acute toxicity is Category 3.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information