NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Diethyl chlorothiophosphonate
CAS：2524-04-1

Result：


ID:	22A4220
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Since its flash point 92 degC (closed-cup) (ICSC (1996)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	-	-	-	-	No data available.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Although the substance contains a metalloid (P), the water solubility data 468 mg/L (25 degC) (SRC Phys Prop (Access on Nov. 2010)) is obtained. Therefore it is considered that the substance does not react vigorously with water.
13	Oxidizing liquids	Classification not possible	-	-	-	-	Classification is not possible since no data are available though the substance is an organic compound containing oxygen and chlorine which are chemically bonded to the elements other than carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Six LD50 values for rats of 953, 965, 1225, 1297, 1314 and 1340 mg/kg bw were reported (IUCLID (2000)), and all of them corresponded to Category 4.
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	For the rats, three LD50 values of 714, 794 and 1439 mg/kg bw were reported (IUCLID (2000)) and Category 3 was adopted because the majority corresponded to the category. For the rabbits, based on the LD50 value of 1439 mg/kg bw (IUCLID (2000)), Category 4 was adopted. The substance was classified as Category 3, selecting the rat data of greater hazard category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 values of approximately 20 ppm/L/4hrs and approximately 79.8 ppm/4hrs (IUCLID (2000)), the substance was classified as Category 1. Since the test was carried out under the condition lower than 90% of the saturated vapor pressure concentration, the criterion values for gas were adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 1		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 1 based on the document that the substance caused irritation after 3 minutes of application and caused corrosion after 1 hour of application in the rabbit test (OECD TG404).
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	The substance was classified as Category 1 based on the documented case of "corrosive" in the rabbit test (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law, Supplement 2 (2000)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system)		Warning	H371: May cause damage to organs (respiratory system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In the 2-day inhalation study in rats, the changes reported at the concentration of 104 ppm/4hrs (as vapors: 0.8 mg/L/4hrs) included nose and eye irritation, salivation, dyspnea, swollen lungs in autopsy and lung emphysema in histopathology (IUCLID (2000)). Although the concentration was equivalent to Category 1 judging from the guidance values, the information was derived from the "List 2" information source designated in the GHS classification guidance for the Japanese government and did not meet with the judgment criteria 1b3). Therefore, the substance was classified as Category 2 (respiratory system) in accordance with the guidance document.
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the 14-day inhalation study in rats, which was insufficient for repeated dose toxicity study due to the study using only 4 male rats per group, slight nose irritation, slight thickening of alveolar walls in the lung at 5 ppm (converted dose level as that of 90-day study: 0.0051 mg/L/6hrs), severe nose irritation, dyspnea, thickening of alveolar walls and areas of collapse in the lung at 20 ppm (converted dose level as that of 90-day study: 0.02 mg/L/6hrs) were reported (IUCLID (2000)). Since the dose dependency was confirmed in the multiple parameters with regard to the effects on the respiratory system, the respiratory system was adopted as target organs. Although the concentration was equivalent to Category 1judging from the guidance values, the information was derived from the "List 2" information source designated in the GHS classification guidance for the Japanese government and did not meet the judgment criteria 1b3). Therefore, the substance was classified as Category 2 (respiratory system) according to the guidance document. As relevant information, in the 1-month oral dose study in mice, decline in cholinesterase activity was reported at the dose level of 182 mg/kg/day (converted dose level as that of 90-day study: 60.7 mg/kg/day) (IUCLID (2000)). However, this was not evidenced to classify because no descriptions were given for the other findings such as clinical signs or histological alterations and because the setting of the control group was unspecified.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）