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GHS Classification Result

Chemical Name：2,4-Dichloroaniline
CAS：554-00-7

Result：


ID:	22A4281
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2010
Reference Manual:	GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available.
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification is not possible since no data are available though it contains chemical groups (Inter-reacting groups: haloanilines) associated with self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	The substance is an organic compound containing chlorine which is chemically bonded only to carbon.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 value of 1600 mg/kg bw (PATTY, 5th (2001), BUA 140 (1993)), the substance was classified as Category 4. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)). [For health hazards, refer also to 2,5-dichloroaniline (CAS No. 95-82-9) and 3,4-dichloroaniline (CAS No. 95-76-1).]
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data were available. As relevant information, the substance was classified as "R23/24/25" as chloroanilines in the EU classification (EC-JRC (ESIS) (Access on Jan. 2011)).
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	It was reported that the substance caused moderate irritation to rabbit skin (BUA 140 (1993)), but no details of testing methods were provided. It is also reported that 24-hour application of the substance caused moderate irritation (BUA 140 (1993)), but no details such as test species were provided. Thus, since sufficient data were not available, the classification was not possible. As relevant information, irritation was not reported with isomer of the substance, 2,5-Dichloroaniline (CAS No. 95-82-9) and 3,4-Dichloroaniline (CAS No. 95-76-1) (BUA 140 (1993)).
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data were available. As relevant information, as for its isomers, strong irritation for 2,5-Dichloroaniline (CAS No. 95-82-9) and irritation for 3,4-Dichloroaniline (CAS No. 95-76-1) was reported (BUA 140 (1993)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data were available. As relevant information, positive results in the maximization tests were reported for isomers, 2,5-Dichloroaniline (CAS No. 95-82-9) and 3,4-Dichloroaniline (CAS No. 95-76-1) (BUA 140 (1993)).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro mutagenicity studies, negative results in the Ames test with rat S9 and positive results in the Ames test with hamster S9 were reported (NTP DB (Access on Jan. 2011)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data were available. As relevant information, in the teratology study in rats with the isomer of the substance, 3,4-dichloroaniline (CAS No. 95-76-1), the increase in resorptions (not statistically significant) and delayed ossification were observed at the dose levels that induce maternal toxicity. However, it was reported that the toxicity and malformation were not seen in fetuses at the dose levels that no toxicity was noted in maternal animals (EU-RAR 65 (2006)).
8	Specific target organ toxicity - Single exposure	Category 1 (blood system)		Danger	H370: Causes damage to organs (blood system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	No specific, detailed data on the animal studies and information on humans were available for this substance. The substance, however, was one of the methemoglobin forming substances as likely as 2,5-dichloroaniline (CAS No. 95-82-9) or 3,4-dichloroaniline (CAS No. 95-76-1) (EU-RAR 65 (2006)), and it was reported that acute symptoms of intoxication were methemoglobinemia (cyanosis, fatigue, dyspnea, muscle weakness) (PATTY, 5th (2001)). As for the data on the animal study of 3,4-dichloroaniline (CAS No. 95-76-1), the isomer of the substance, it was reported in the dermal toxicity study in rats that cyanosis was noted in all exposure groups treated at the dose levels of 130-1500 mg/kg equivalent to Category 1 or 2 (EU-RAR 65 (2006)). Based on the information, since methemoglobinemia was also taken into account for the evaluation of this substance, the substance was classified as Category 1 (blood system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (blood system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	No specific detail data on the animal studies and information on humans was available for this substance. The substance, however, was one of the methemoglobin forming substances as likely as 2,5-dichloroaniline (CAS No. 95-82-9) or 3,4-dichloroaniline (CAS No. 95-76-1) (EU-RAR 65 (2006)), and it was reported that in human case of cyanosis, the cause was exposure to dichloroaniline (EU-RAR 65 (2006)). As for the data on the animal study of 3,4-dichloroaniline (CAS No. 95-76-1), the isomer of the substance, it was reported in the 2-week vapor inhalation study in rats that raised methemoglobin level and accumulation of hemosiderin in the spleen were found at concentrations of 0.045 mg/L/6hrs (converted value as that of 90-day study: 0.007 mg/L/6hrs: equivalent to Category 1) or higher (EU-RAR 65 (2006)). Based on the information, since methemoglobinemia was also taken into account for the evaluation of this substance, the substance was classified as Category 1 (blood system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 2 from its 48h-EC50 = 4.2 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1995).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (4w-BOD degradation rate tested by OECD TG301C = 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1990)).
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）