GHS Classification Result

Chemical Name:4-(1-Methylethenyl)phenol
CAS:4286-23-1

Result:
ID: 22A4290
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2010)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though it contains chemical groups (unsaturated bonds) associated with self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 value of 585.8 mg/kg bw (OECD TG 401, GLP-compliant) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on Jan. 2011)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The substance was classified as "Not classified" based on the negative results in the micronucleus test using mice (OECD TG474) (in vivo mutagenicity test) (SIAP (2009)). As relevant information, as for in vitro studies, negative results in the Ames test (OECD TG471, GLP-compliant) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2002)) and positive results in the chromosome aberration test using CHL/IU cells (OECD TG473, GLP-compliant) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2002)) were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the oral reproduction/developmental toxicity screening test in rats (OECD TG421, GLP-compliant), as for the toxic effects of parent animals, temporary salivation after administration in males and thickening of the mucosa and diffuse squamous hyperplasia in the forestomach in both sexes were observed at 60 mg/kg group. As for the reproductive effects, no effects related to the treatment were observed in the estrous cycle, copulation or fertility. In addition, no effects related to the treatment were observed in gestation length, parturition, and lactation. As for the pups, there were no changes related to the treatment in terms of morphology, body weight and viability ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (2002)). However, since the fetal inspections at the end stage of pregnancy period were not carried out for evaluation of developmental effects, data were insufficient. Therefore, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the acute oral toxicity study in rats (OECD TG 401, GLP-compliant), three rats in 600 mg/kg group in both sexes and all rats in 1200 mg/kg group died from 6 hours after dosing until day 3. The survivors of 600 mg/kg group in both sexes revealed suppression of body weight gain. As clinical symptoms, the signs of toxicity appeared at one to six hours after dosing in males and females of 600 mg/kg group included bradypnea, hypothermia, lateral position, decreased locomotor activity, and staining of fur around the external urethral orifice, etc. As necropsy findings, dark reddish spots on the mucosa of glandular stomach or forestomach were observed in female decedents in 600 and 1200 mg/kg groups, however, no macroscopic changes were noted in the survivors in both sexes ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). The above findings were the effects observed within the range of dose levels corresponding to Category 2 of the guidance values, but it was difficult to specify the target organ(s) based merely on the information. Thus, the substance was classified as Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 28-day repeated dose oral toxicity study in rats (CSCL guideline, GLP-compliant), the pathological findings observed at the dose levels within the guidance values included thickening of the forestomach in the 400 mg/kg group at necropsy, and hyperplasia of squamous epithelium of the forestomach and of the gastric border area in the 100 mg/kg/day (converted value as that of 90-day study: 31.1 mg/kg/day) or higher dose groups ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). Moreover, perilobular fatty change in the liver was observed in females of the 300 mg/kg/day (converted value as that of 90-day study: 93.3 mg/kg/day) or higher dose groups and in males of the 400 mg/kg/day (converted value as that of 90-day study: 124.4 mg/kg/day) group ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)). As for the gastric effects, although the irritating potency of the substance was unknown, because the possibility of its local irritant effects or for the physical effects attributed to repeated oral doses through the gastric tube could not be denied, they were not evidenced to classify. On the contrary, higher value of the liver weight and perilobular fatty change were observed at 300 - 400 mg/kg/day (converted value as that of 90-day study: 93.3 - 124.4 mg/kg/day, near the upper limit dose level of the range of the guidance values) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on Jan. 2011)), however, the toxicological significance of these findings could not be judged from the only data provided without any further data in the higher dose levels. In conclusion, "Classification not possible" was justified due to lack of sufficient data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 2 from its 48h-EC50 = 4.1 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1999).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2002)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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