GHS Classification Result （Revision of the past classification result）

Chemical Name：Benzenesulfonic acid, 4,4'-oxybis-, dihydrazide
CAS：80-51-3

Result：
ID: 22B4502
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - The substance contains adjacent nitrogen atoms (sulfonyl hydrazides) as chemical groups associated with explosive properties and its oxygen balance is -116.06 which is higher than the -200 threshold and it is not excluded from Explosives, but pure substance is classified into Self-reactive properties Type D (UN3226) in UNRTDG. Therefore it is not classified as "Explosives", it is classified as "Not classified".
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - It is reported as incombustible (ICSC (J) (1998)), but also reported as combustible (ACGIH (2001)). Since no test data measured by prescribed methods in UNRTDG are available, classification is not possible.
8 Self-reactive substances and mixtures Type D Danger H242: Heating may cause a fire P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P411: Store at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials.
P501: Dispose of contents/container to ... 		It contains consecutive nitrogen atoms (sulfonyl hydrazides) as chemical groups associated with explosive properties and pure substance is classified into Division 4.1 (UN3226) Type D in UNRTDG.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - There is a description about autoignition temperature that the more recently calculated value of 78 degC for critical ignition temperature is appreciably lower than the previous value of 90 degC. (Bretherick (7th, 2007)), and it is considered that the substance does not ignite at room temperature, therefore it is classified as "Not classified".
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though this substance contains oxygen which is chemically bonded to the element other than carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compound containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values of > 2000 mg/kg ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on May 2009)) and 2300 mg/kg (ACGIH (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).
1 Acute toxicity （Dermal） Classification not possible - - - - The rabbit LD50 value of > 200 mg was reported (ACGIH (2001)). Since the value did not provide the basis for classification and the sufficient data were not available, the classification was not possible.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was classified as "Not classified" based on the documented case of "not irritating" resulted from the rabbit test (ACGIH (2001)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The substance was classified as Category 2B based on the documented case of "slight irritant" resulted from the rabbit test (ACGIH (2001)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - The substance was classified as "Not classified" based on the negative results in the micronucleus test using erythrocytes of mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (ACGIH (2001)). As relevant information, as for in vitro studies, positive results ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on May 2009), ACGIH (2001)) and negative results (ACGIH (2001)) in the Ames tests, and positive in the chromosome aberration test using Chinese hamster cultured cells (CHL/IU) ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on May 2009)), were reported.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In the oral reproduction/developmental toxicity screening test in rats (OECD TG421, GLP-compliant), no reproductive effects on parental animals and developmental effects on the offspring were observed ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (Access on May 2009)). However, since the data about the development of the offspring containing teratogenic effects were insufficient, the substance was classified as "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral toxicity test in rats (OECD TG 401, GLP-compliant), it was reported that deaths occurred in 1500 and 2000 mg/kg, and that the neurotoxic signs such as tip-toe gait and/or paralytic gait were observed in females at 1000 mg/kg and in both sexes at 1500 and 2000 mg/kg ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on May 2009)). Based on the guidance values that the findings were noted, the substance was classified as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, blood), Category 2 (kidney, liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, blood)
H373: May cause damage to organs through prolonged or repeated exposure (kidney, liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the repeated dose 28-day oral toxicity study in rats (OECD TG 407, GLP-compliant), neurotoxicity such as reduced grip strength of hind limbs and paralytic gait and/or degeneration of peripheral nerve fibers were observed at dose levels of 30 mg/kg (converted value as that of 90-day study: 9.3 mg/kg/day) or more, and anemia-like changes accompanied by reductions in hematocrit values and hemoglobin contents in females at 100 mg/kg/day (converted value as that of 90-day study: 31.1 mg/kg/day) or more as well as possible reactions to anemia consisting of high values of reticulocytes and extramedullary hematopoiesis in the spleen in groups at 30 mg/kg (converted value as that of 90-day study: 9.3 mg/kg/day) or more, were found ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on May 2009)). Thus, the substance was classified as Category 1 (nervous system, blood). Furthermore, nephrotoxicity such as fatty degeneration of tubular epithelium in proximal tubules in addition to high values of inorganic phosphate or urea nitrogen and low value of chloride as well as hepatotoxicity such as centrilobular hypertrophy of hepatocytes or perilobular fatty change in addition to low value of glucose, high values of total cholesterol and triglyceride and an increase in liver weight were observed at 100 mg/kg (converted value as that of 90-day study: 31.1 mg/kg/day) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access on May 2009)). Based on the information, the substance was also classified as Category 2 (kidney, liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 2.9 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 2% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information