GHS Classification Result （Revision of the past classification result）

Chemical Name：Propene, 1,3-dichloro-
CAS：542-75-6

Result：
ID: 22B4513
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since flash point is 25 degC (closed-cup) (ICSC (J), 2004), the substance is classified into Category 3. In addition the substance is classified as Class 3, PG II or III in UNRTDG (UN2047).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since the substance is classified into Class 3 in UNRTDG (UN2047) and it is not classified as Pyrophoric substance, it is classified as "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Since the substance is classified into Class 3 in UNRTDG (UN2047) and self-heating property (4.2) was not assigned, it is classified as "Not classified".
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing chlorine (but not oxygen) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available. As relevant notes, the substance corrodes aluminum and rubber. It is also reported that it corrodes steel in humid, wet condition or at the high temperature state (Hommel (1996)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Eighteen LD50 values for rats (both sex) of 300, 224, 713, 470, 121, 150, 519, 304, 325, 85, 117, 78, 127, 130, 110 - 250, 57, 560 and 510 mg/kg obtained from the individual tests documented in the "List 1" information source designated in the GHS classification guidance for the Japanese government (Registration and application document of pesticide (1997), ACGIH (2005), ATSDR (2008), IARC 41 (1986) and EHC 146 (1993)), were taken into consideration. Eleven of them corresponded to Category 3, and seven of them corresponded to Category 4. The substance was classified as Category 3, since the majority of obtained data corresponded to it.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Two LD50 values for rabbits of 333 and 504 mg/kg (Registration and application document of pesticide (1997) and IARC 41 (1986)) and five LD50 values for rats of 1000, 1300 - 2000, 423, 1575 and 1090 mg/kg (PATTY, 5th (2001) and EHC 146 (1993)) reported in the "List 1" information source designated in the GHS classification guidance for the Japanese government were taken into consideration. For rabbits, Category 3 was adopted, since both of them corresponded to Category 3. And for rats, Category 4 was adopted, since two of them corresponded to Category 3 and three of them corresponded to Category 4. Based on the rabbit data of greater hazard, the substance was classified as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up. 		Nine LC50 (4-hour exposure) values for rats for males and females (855 - 1035, 904, 1000, 727, 595 - 676, 670, 744, 1075 and 1190 ppm) were reported in the data from the "List 1" information source designated in the GHS classification guidance for the Japanese government (Registration and application document of pesticide (1997), IARC 41 (1986) and EHC 146 (1993)). All of them corresponded to Category 3, therefore, the substance was classified as Category 3. As the LC50 values were lower than 90% of the saturated vapor pressure concentration (44737 ppm), it was judged as "vapor hardly coexisting mists" and the criterion values for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There were three reports of rabbit tests. In the first report, 4-hour occlusive application of 0.5 mL of the substance caused slight to moderate erythema and moderate to severe edema, these changes were still present in some of the animals after 14 days (EHC 146 (1993)). In the second study, semi-occlusive application of the substance for 4 hours caused well-defined erythema and moderate edema, and symptoms disappeared completely within 14 days (EHC 146 (1993)). In the third study, 4-hour application of 0.5 mL of the substance caused erythema and slight edema and symptoms disappeared completely within 21 days (EHC 146 (1993)). Based on the information, the substance mainly caused slight to moderate erythema and slight to severe edema, and symptoms disappeared completely within 14 - 21 days. Thus, the substance was classified as Category 2. As relevant information, the substance was classified as "Xi; R36/37/38" in the EU classification.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In the rabbit test, instillation of 0.1 mL of test substance into conjunctival sac caused slight to marked redness, slight to moderate chemosis, reddening of the iris, and discharge. In one animal, irritative reactions of the cornea were found, and those recovered within 14 days (EHC 146 (1993)). In the other rabbit test, moderate to severe conjunctival irritation and minor irritative changes of the cornea, chemosis, and radial responses were observed, and the symptoms disappeared completely within 14 days (EHC 146 (1993)). Based on the information, because the substance caused moderate or more irritation, radial responses, and minor changes of the cornea and the symptoms all disappeared within 14 days, the substance was classified as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In the sensitization tests using guinea pigs, positive rates of two tests (Buehler test) without adjuvants were 25% (5/20) and 90% (9/10), respectively. And in the other two tests (maximization test) with adjuvants, positive rates were 100% (20/20) and 80% (16/20), respectively (EHC 146 (1993)). These positive rates were all beyond the criteria for judging for positive. In human cases, sensitization to the substance was reported in process operator in pesticide manufacturing facility. He developed bullous dermatitis. Patch test with the substance elicited positive responses and it was concluded that the worker was probably sensitized to insecticide formulation containing 95% of the substance (ACGIH (2005)). Based on the information, the substance was classified as Category 1.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2 based on the positive results in the micronucleus test using bone marrow cells from mice orally administered (IARC 71 (1999)) and in the chromosome aberration test using bone marrow cells from mice intraperitoneally administered (NTP DB (Access on Jun. 2009)) (in vivo mutagenicity test in somatic cells). As relevant information, as for other in vivo test results were also obtained, i.e., negative results in the dominant lethal test (in vivo inheritable mutagenicity test in germ cells) using rats by inhalation exposure (ACGIH (2005)), negative results in the other micronucleus test using bone marrow from mice orally or intraperitoneally administered (IARC 71 (1999)) and positive results in the DNA damage test using the liver, kidney and others of rats orally or intraperitoneally administered (IARC 71 (1999)). As for in vitro studies, positive results in the Ames test, negative or positive results in the chromosome aberration test (NTP DB (Access on Jun. 2009), Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1996)) and positive results in the mouse lymphoma assay (NTP DB (Access on Jun. 2009)) were reported. EFSA (and EU) proposed "Muta. Cat. 3; R68" from the positive data of genotoxicity tests, but the proposal was not approved because there was a possibility of the effects of impurities and stabilizers (Evaluation of effect for the food safety (Food Safety Commission) (2009)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As for the major activity for evaluation of carcinogenicity by authorities, the criteria of "Group 2B" in the IARC (IARC 71 (1999)), "A3" in the ACGIH (ACGIH (2005)), "B2" in the EPA (IRIS (2003)) were reported. Therefore, the substance was classified as Category 2. As relevant information, in the 2-year oral administration tests in rats and mice, an increase in the incidence of papilloma or carcinomas of squamous epithelium of forestomach were found. Furthermore, an increase in the incidence of liver tumors in rats, and increase in the incidences of alveolar/bronchiolar tumors and transitional cell carcinomas of bladder epithelium in mice were reported (NTP TR 269 (1985), IRIS (2003)).
7 Reproductive toxicity Not classified - - - - In the two-generation inhalation study in rats, as parental toxicity, decreased body weight and histopathological changes in the nasal mucosa were observed. However, no adverse effects were observed in reproduction or neonatal growth or survival (EHC 146 (1993)). In addition, in the developmental study in pregnant rats or rabbits by inhalation during the organogenetic period, decreased body weight gain was observed as the general toxicity of dams in both animal species, however, no adverse effects were observed in reproductive indices such as the number of implantations, resorptions, litter size. There was no evidence of a teratogenic or embryotoxic response (EHC 146 (1993)). Based on these results, there were no adverse effects on sexual functions and fertility of parental animals, or development of offspring. Therefore, the substance was classified as "Not classified"
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, lung) Danger H370: Causes damage to organs (nervous system, lung) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As for the information on humans, it was reported that inhalation exposure at lower concentrations resulted in depression of central nervous system (EHC 146 (1993)), and that accidental poisoning by high-dose exposure caused acute neurotoxic symptoms (ACGIH (2005)). In the acute oral toxicity study in rats (LD50 value: 110-250 mg/kg), the signs observed included lethargy, hunched posture, ataxia and tremors (IUCLID (2000)). In the acute dermal toxicity study in rats (LD50 value: 800 - 2000 mg/kg), the signs observed also included lethargy, hunched posture and ataxia, and loss of righting reflex additionally (EHC 146 (1993), IUCLID (2000)). In both routes, the symptoms were noted within the range of doses corresponding to Category 1 of the guidance values, therefore, the substance was classified as Category 1 (nervous system). Further, in these acute toxicity studies in rats, in addition to the neurological symptoms, decreased respiratory rate was observed in each route of three routes for oral, inhalation and dermal. As the autopsy findings in the survivors, congestion of the lungs was found in both oral and dermal routes, while pale and swollen lungs were reported in inhalation route (EHC 146 (1993), IUCLID (2000)). Based on the information, the substance was classified as Category 1 (lung).
9 Specific target organ toxicity - Repeated exposure Category 2 (stomach, upper respiratory tract, urinary bladder) Warning H373: May cause damage to organs through prolonged or repeated exposure (stomach, upper respiratory tract, urinary bladder) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 13-week repeated dose oral study in rats, hyperplasia of basal cells and prominence of mononuclear cells were observed in the proximity of the basement membrane of the forestomach at the dose greater than 15 mg/kg/day (ACGIH (2005)). In the 2-year study, hyperplasia of basal cells or epithelium of the forestomach was also observed as non-neoplastic lesions at 25 or 50 mg/kg/day (NTP TR 269 (1985)). Because the lesions in the forestomach occurred at the dose levels equivalent to Category 2 of the guidance values, the substance was classified as Category 2 (stomach). While as for the information on humans, a farmer in good health developed pain in the ear, nasal mucosa and pharynx by exposure to small quantities of the substance leaked from the hose during his work for soil treatment over 30 days. Hospital examination showed pain in the external ear, hyperemia, superficial ulcerations of the nasal mucosa, and inflammation of the pharynx (EHC 146 (1993)). In the 13-week inhalation (as vapors) studies in rats and mice, it was reported that degeneration of the olfactory epithelium and hyperplasia of the epithelium of respiratory tract was noted at the concentrations of 409 mg/m3 (corresponding to Category 2 of the guidance values) or higher in both species (EHC 146 (1993)). Based on the information, the substance was classified as Category 2 (upper respiratory tract). Additionally, in the 13-week inhalation study in mice, hyperplasia of the transitional epithelium of the urinary bladder was observed at the same dose levels, and the change was also reported in the 2-year inhalation study (IARC 71 (1999)). There was a description stating that the nasal mucosa and urinary bladder were the target organs in inhalation exposure (EHC 146 (1993)). Based on the information, the substance was classified as Category 2 (urinary bladder). Therefore, the result of the classification was Category 2 (stomach, upper respiratory tract, urinary bladder). In addition, it was reported that increases in the incidence of squamous cell papilloma and/or carcinoma in the forestomach and those of carcinoma of transitional cells in the urinary bladder were noted following two-year oral administration (NTP TR 269 (1985)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 48h-LC50 = 0.09 mg/L for crustacea (Daphnia magna) (EHC 146, 1993, etc.).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1992)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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