GHS Classification Result （Revision of the past classification result）

Chemical Name：Tetramethyl silicate
CAS：681-84-5

Result：
ID: 22B4518
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Based on the reports of flash point 20 degC (closed-cup) (ICSC (J) (1997)), which is < 23 degC, and initial boiling point 121 degC (ICSC (J) (1997)), it is classified into Category 2.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - Classification is not possible since no data are available though the substance contains a metalloid (Si).
13 Oxidizing liquids Classification not possible - - - - Classification is not possible since no data are available though the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - The description that 700 mg/kg was the lethal dose for rats was reported (Assessment report in Holland (2004)). Since the category could not be specified from the data only, the classification was not possible.
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 value of 17400 mg/kg (Assessment report in Holland (2004)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value (4-hour) of 53 ppm (0.335 mg/L) (Assessment report in Holland (2004)), the substance was classified as Category 1. Since the test concentration (53 ppm) was lower than 90% of the saturated vapor pressure concentration (2800 ppm), the criterion values for gas were adopted. In addition, the rat LC50 value of 125 - 250 ppm (ACGIH (2001)) was reported in the "List 1" information source designated in the GHS classification guidance for the Japanese government. However, since it was the results of the range-finding study and the year of the report was as old as 1951, the datum was not adopted as the basis of the classification.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - In the rabbit test, 30-minute application of the substance caused slight erythema, but substantial injury was not observed (Assessment report in Holland (2004)). The substance was classified as "Classification not possible" because no other data were available.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Instillation of the substance to rabbit eyes caused edema and necrosis of the eyelid, and the substance was concluded as very severe eye irritant (ACGIH (2001)). In another test, instillation of the substance caused inducing of burn, following inflammation of the eyelids, edema of the mucous membrane, necrosis of the iris, and opacity of the cornea (Assessment report in Holland (2004)). In another rabbit test, irritation index score was 9 by grading according to 10 ranks (Assessment report in Holland (2004)). In the industrial experience, both in the United States and Europe, it was confirmed that the severe ocular hazard by the substance ranging from eye pain to blindness (ACGIH (2001)). Based on the information, the substance was classified as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the inhalation study (0.195 - 0.555 mg/L/4hrs) in rats, it was reported that the main findings at necropsy were pulmonary injuries which varied from diffuse small lesions extending to all lobes (Assessment report in Holland (2004)). And it was reported that pulmonary edema and histological abnormalities in the lung were found by inhalation exposure to guinea pigs at 0.63 mg/L/4hrs (Assessment report in Holland (2004)). It was also reported that pneumonitis was observed at concentrations of 7.63 to 13.2 mg/L/4hrs in the inhalation study in rabbits, and hemorrhagic and edematous changes were found in the wide area of the lung (Assessment report in Holland (2004)). Although the results described above corresponded to Category 1 judging from the guidance values, the information was obtained from the "List 2" information source designated in the GHS classification guidance for the Japanese government, and all of the studies were not in accordance with OECD TG and not GLP-compliant. Thus, the substance was classified as Category 2 (lung). In addition, it was reported that renal disturbances were found at 700 mg/kg in the oral dose study in rats (Assessment report in Holland (2004)), however, the dose level was lethal and no descriptions of histopathological findings were given. Therefore, the information was not adopted as the evidence to classify.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 28-day inhalation exposure study in rats, occurrence of the inflammatory changes of upper respiratory tract and bronchial tubes accompanied by severe pulmonary disease was seen at 0.187 mg/L (converted concentration as that of 90-day study: 0.058 mg/L) (ACGIH (2001)). As the effects of inhalation exposure to guinea pigs, hemorrhages and edema in the lungs were reported in addition to ocular changes (Assessment report in Holland (2004)). Since the effects in rats were observed within the dose range of Category 1 of the guidance values, the substance was classified as Category 1 (respiratory organs). Moreover, it was reported that renal disturbances were reported as toxic effect at the dose range of 40 - 240 mg/kg (converted dose level as that of 90-day study: 13.3 - 80 mg/kg/day) in the 30-day oral dose study in guinea pigs (Assessment report in Holland (2004)), and that the kidney was listed in one of the target organs of the substance (NIOSH Pocket Guide to Chemical Hazards (2005)). As described above, since the effective dose levels in the oral administration corresponded to Category 2, the substance was classified as Category 2 (kidney). In addition, ocular lesions were reported in the inhalation exposure studies in both rats and guinea pigs (Assessment report in Holland (2004)), however, they were considered as local effects, and Category 1 as a hazard class of serious eye damage/eye irritation was adopted. Thus, they were not evidenced to classify in this hazard class.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information