GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Calcium nitrate
CAS：10124-37-5
Result：
| ID: | 22B4524 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | The substance does not fall under Explosives since it is classified into Division 5.1 in UNRTDG (UN1942) though it contains chemical groups (-NO3) associated with explosive properties. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | The substance is classified as Oxidizing solid. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (Hommel (1996)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although the substance contains a metal (Ca) in the molecule, the water solubility data as "complete" (121.2 g/100 mL (ICSC (2003)) is obtained and it is judged not to react vigorously with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Category 3 |
|
Warning | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The substance is classified into Division 5.1, PG III (UN1454) in UNRTDG. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The substance is not an organic compound. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 value of 9285 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | Although the result for rats that no toxic effect was observed by administration of the test material consisting 81 - 93% of the substance at 10000 mg/animal (equivalent to 1.6 g/kg by estimation at 200g of body weight and 81% of purity) was reported (IUCLID (2000)), the classification was not possible due to lack of sufficient data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | There was no test data of animals. Six male farmers revealed corrosive wound after contact with fertilizer (calcium nitrate), but no information on composition and concentration of the fertilizer or exposure time was provided (IUCLID (2000)). The substance was classified as "Classification not possible" due to insufficient data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro mutagenicity study, negative results in the DNA damage repair test using E. coli were reported (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | The classification was not possible due to no data available. As relevant information, the IARC (IARC Vol.94 (2010)) described that the evidence of carcinogenicity in humans for nitrates in drinking water was uncertain. And also, it was evaluated the carcinogenicity as "Group 2A" under the conditions that nitrates or nitrites could be nitrosated in vivo after oral ingestion. The comprehensive evaluation of the IARC described additionally as follows: There is an active endogenous nitrogen cycle in humans that involves nitrates and nitrites, which are interconvertible in vivo. Nitrosating agents that arise from nitrites under acidic gastric conditions react readily with compounds which are easily nitrosated, especially secondary amines and amides, to generate N-nitroso compounds. These nitrosating conditions are enhanced following ingestion of additional nitrates, nitrites or nitroso compounds. Some of the N-nitroso compounds have the possibility to form known carcinogens in humans under these conditions. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
|
Danger | H370: Causes damage to organs (blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There were no reports on human health for the substance concerned. With regard to information for general water-soluble nitrates, it was reported that 15 soldiers who ingested sodium nitrate by mistake instead of table salts became methemoglobinemia. Of them, 13 ingested about 15 g died, while two ingested 5 g survived (ECETOC TR 27 (1988)). Based on the information, the substance was classified as Category 1 (blood). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
With regard to chronic toxicity of general water-soluble nitrates, there were numerous reports of increased methemoglobin concentrations observed in the infants who ingested meal or water containing nitrates, and case reports of methemoglobinemia observed in the patients administered sodium nitrate or ammonium nitrate as a diuretic agent or in the patients treated with ammonium nitrate as an urolithiasis-preventive agent were presented (ECETOC TR27 (1988)). Based on the information, the substance was classified as Category 1 (blood). Besides, the effects on the heart, etc. were reported as ones of nitrates, but these were considered to be secondary effect by methemoglobinemia-induced hypoxia (EHC 5 (1978)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Classified as "Not classified" from its 96h-LC50 = 2400 mg/L for fish (Lepomis macrochirus) (AQUIRE, 2010). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Classified as "Not classified" since it is not non-water soluble (Very soluble in water (Merck 14th, 2006)) and its acute toxicity is low. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |