GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 80-54-6 |
| Chemical name | p-tert-Butyl-alpha-methylhydrocinnamic aldehyde |
| Substance ID | 23A5005 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Not classified | - | - | - | It was classified as "Not classified" because a flash point of 120 degrees C [closed cup] (HSDB (2009)) is above 93 degrees C. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not to ignite at normal temperatures from an ignition point of 250 degrees C (IUCLID (2000)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | On the basis of an LD50 value of 3700 mg/kg for rats (EPA HPV (2005)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis of 2 LD50 values for rabbits of >5000 mg/kg and >5 ml/kg ( > 5250 mg/kg (both EPA HPV (2005))), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis of the facts that erythema and oedema were observed throughout the observation period of 7 days after application in both two tests in which 0.5 mL of the test substance was applied to rabbits for 4 hours (OECD TG 404; GLP), and Primary Dermal Irritation Indexes (PII) were 4.56/8 and 3.58/8 respectively (ECETOC TR66 (1995)), it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | On the basis of both "not irritating" in a report on two tests using rabbits (IUCLID (2000)), it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Category 1 | |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
It was classified in Category 1 because this substance is listed as sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006). Besides, several conflicting results, "sensitizing" and "not sensitizing", were reported in guinea pig maximization tests (IUCLID (2000)), and conflicting results in human patch tests were also reported (IUCLID (2000)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
On the basis of a negative result in a micronucleus test using bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (EPA HPV (2005)), it was classed as "Not classified." Besides, a negative result in an Ames test in an in vitro test is reported (EPA HPV (2005)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） | |
H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
On the basis of an LD50 value of 3700 mg/kg for rats in an acute oral toxicity test in which lethargy and flaccidity were observed at doses of 2470 mg/kg or higher (EPA HPV (2005)), it was classified in Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (testis) |  |
H373 |
P260 P314 P501 |
On the basis of the findings observed at doses of 25 mg/kg/day or higher, which corresponds to values of Category 2 in Guidance, in a 90-day oral administration test for rats (2 to 50 mg/kg/day) such as spermatoceles and testicular atrophy which remained during the observation period after dosing (EPA HPV (2005)), it was classified in Category 2 (testis). Besides, decreases in cholesterol and in cholinesterase activity observed at the same dose were not used as bases for classification because other relevant findings were not obtained. On the other hand, adverse effects related to this substance were not reported in a 13-week oral administration test in which dogs were administrated up to 200 mg/kg/day (EPA HPV (2005)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - |
H401 |
P273 P501 |
From 96-hour LC50 = > 2.2 to 4.6 mg/L for fish (Leuciscus idus melanotus) (IUCLID, 2000), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |  |
H411 |
P273 P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 2 due to lack of rapid degradability (a degradation rate by BOD: 8 % (the existing chemicals survey program, 1995)), and acute toxicity Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/6/29 Addition of Rationale for the classification |