GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 90-00-6 |
| Chemical name | 2-Ethylphenol |
| Substance ID | 23A5009 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of > 60 degrees C and <= 93 degrees C in a prescribed closed-cup test method may be judged from 78 degrees C [unkown] (Gangolli (2nd,1999)) in an unknown test method, therefore, it was classified in Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
From an LD50 value of 600 mg/kg for mice (RTECS (1997): the original literature, Pharmazie. 30, 147, 1975), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
No data. Besides, the information on 4-ethylphenol was reported. Severe ocular irritation that consists of moderate to severe conjunctival irritation (redness, chemosis, discharge, necrosis), iritis, corneal opacity, stippling, and ulceration was shown 24 hours after application of 0.1 mL/kg to four rabbits. The severe irritation was still evident in all animals until seven days after application. And one animal exhibited pannus and one animal exhibited hair loss around the eye. (HSDB (2003)) |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test in an in vitro test reported a negative (NTP DB (Access on Dec. 2010)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
No data. Besides, a combined repeated dose toxicity test with reproductive/developmental toxicity screening test (OECD TG 422, GLP) in which a mixture of 3 isomers including this substance was orally administered to rats reported that general toxicity such as decreases in food consumption and weight gain in males and salivation in females was observed. But no adverse effects of test substance administration on sexual function and fertility were observed (US EPA HPV (2006)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
No data. Besides, a test in which rats were orally dosed a mixture of 3 ethylphenol isomers including 25.9% of this substance (OECD TG 425, GLP) reported that signs such as hypersalivation, blepharoptosis, decreased spontaneous motility, ataxia, tachypnea, righting reflex, anomalies in limbs observed at 1750 mg/kg immediately after dosing disappeared by seven days after administration. (USEPA/HPV (2006)) In addition, an oral dose of 2000 mg/kg of 4-ethylphenol in rats reported that no death in both males and females was observed and observed signs of staggering gait followed by proneness or recumbency, and tachypnea disappeared by 2 hours after dosing. After that, no symptoms by day 14 and no dose-related abnormalities in both males and females in necropsy were observed. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2010)) |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
No data. Besides, in a combined repeated dose toxicity test with reproductive/developmental toxicity screening test (OECD TG 422, GLP) in which rats were orally administered a mixture of 3 isomers at 30 to 245 mg/kg/day including this substance, no dose-related effects except dirty hair, decreases in food consumption and a weight gain in males, and salivation in females were reported. (US EPA HPV (2006)) In addition, in a 28-day repeated oral administration test of 4-ethylphenol to rats, increased liver weight, squamous cell hyperplasia of a forestomach in pathological histology at 300mg/kg or higher, and additionally, staggering gait, symptoms like salivation, low body weight and food consumption, and increased kidney weight at 1000 mg/kg were observed. All changes recovered or showed recovery tendencies at the end of a recovery period. NOELs under conditions of this test were reported 100 mg/kg/day for males (converted to a 90-day equivalent: 31.1 mg/kg/day) and 300 mg/kg/day for females (converted to a 90-day equivalent: 93.3 mg/kg/day). (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Aug. 2010)) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement. Hazard statement and Precautionary statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2017/1/30 Addition of Rationale for the classification |