| Item | Information |
|---|---|
| CAS number | 100-18-5 |
| Chemical name | 1,4-Diisopropylbenzene |
| Substance ID | 23A5014 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 76 degrees C [closed cup] (GESTIS (Access on Dec. 2010)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It was classified as "Not classified" because it was judged that it does not ignite at normal temperatures from an ignition point of 449 degrees C for a mixture of diisopropyl benzene (1,3- and 1,4-) (Ullmanns (E) (6th, 2003)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | On the basis of 2 rat data (LD50 > 3200 mg/kg bw (USA EPA /HPV (2003)) and one death out of ten at 5000 mg/kg (SIDS (Access on Dec. 2010)), it is classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
Lack of data. Besides, a test using rabbits reports that an irritation score of diisopropyl benzene rated as the lowest one on a scale of one to ten (HSDB (2003)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
No data. Besides, negatives in both an Ames test and a chromosomal aberration test using CHL/IU cells are reported as in vitro tests on an isomer mixture whose ratio is unknown (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2010)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
No data. Besides, a preliminary reproduction toxicity screening test (OECD TG 421: GLP), in which an isomer mixture was orally administrated to rats, reports that no adverse effects on males, females and offspring were observed even at a dose of 750 mg/kg (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2010)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
After oral administration, in which 4 male and 4 female rats in one dose were orally dosed at 1600 or 3200 mg/kg, no death but weakness and rough hair coats were observed. No clinical signs were observed by 4 hours after administration. No further abnormal clinical signs were observed at any time during the 14-day observation period. All animals gained weight during the study (US EPA HPV (2003)). The above result indicates that serious adverse effects do not occur at 2000 mg/kg/day as an upper limit in Guidance values. Therefore it corresponds to "Not classified" in an oral route, but it was classified as "Classification not possible" in specific target organ toxicity (single exposure) because judgments in other routes are not possible due to no data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A 15-day oral administration test to rats reports that no adverse effects at 100 mg/kg/day (converted to a 90-day equivalent value: 16.7 mg/kg/day) were observed, and slight increases in platelet and monocyte, decreased glucose, increased serum creatinine were observed at 1000 mg/kg/day (converted to a 90-day equivalent value: 166.7 mg/kg/day), but no pathological effects were found (US EPA HPV (2003)). It was classified as "Classification not possible" due to lack of data because judgment only from this data cannot be made due to a test only using males and short duration of administration as 15 days (a number of dosing 11 times). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
|
2016/6/29 Addition of Rationale for the classification |