GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 100-43-6 |
| Chemical name | 4-Vinylpyridine |
| Substance ID | 23A5015 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 50 degrees C [closed cup] (GESTIS (Access on Jan. 2011)) is >= 23 degrees C and <= 60 degrees C, therefore, it corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - |
The classification is not possible due to no data although it contains a chemical group related to self-reactivity (unsaturated bond). Besides, it is class 6.1 subsidiary risk 3, 8PGII in UNRTDG (UN3073: VINYLPYRIDINES, STABILIZED), and it is conceivable that that containing a stabilizer is equivalent to Type G because it does not correspond to self-reactive. In addition, that not containing a stabilizer is judged to be Type A because that corresponds to dangerous goods forbidden from transport in UNRTDG. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 440 degrees C (GESTIS (Access on Jan. 2011)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of LD50 values of 100-200 mg/kg for rats (PATTY (5th, 2001)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - |
The classification is not possible due to lack of data because the category cannot be determined only from a reported LD50 value of < 500 mg/kg bw for guinea pigs (PATTY (5th, 2001)). Besides, it corresponds to Category 3 or lower. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 | |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of an LC50 value of 0.38 mg/L/2h = 0.27 mg/L/4h = 62.79 ppm/4h for mice (HSDB (2002)), it was classified in Category 1. Besides, a reference value of gasses was applied because the toxicity value (0.38 mg/L = 88.4 ppm) is lower than 90 % of the saturated vapour pressure concentration (2237 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis of an evaluation result as "severe skin irritation" in a rabbit test (PATTY (5th, 2001)), it was classified in Category 2. Besides, there is information on vinyl pyrimidine that "direct skin contact with the liquid results in burning pain, followed by fairly severe skin burns" (HSDB (2002)). |
| 3 | Serious eye damage/eye irritation | Category 2A | |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
On the basis of a report in which "instillation of the undiluted liquid caused severe eye irritation in rabbits" (PATTY (5th, 2001)), it was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Category 1 | |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
This substance is listed as sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006). Besides, a positive result in a skin sensitization test by murine LLNA in which the test chemicals demonstrated a greater than threefold increase in lymph node cells proliferation was reported (HSDB (2002)), on the other hand, several skin sensitization results in human exposure to this substance were reported ((Initial Risk Assessment, 18, NITE (2005)), (PATTY (5th, 2001), (HSDB (2002))). It was classified in Category 1 from the above knowledge. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, a negative result in an Ames test in an in vitro test is obtained (PATTY (5th, 2001). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） | |
H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
There is information that human exposure to this substance during laboratory use caused mild and transient irritations to eye, nose, and throat (PATTY (5th, 2001)) and a transient mucous membrane irritation (HSDB (2002)). From a report on a test using rabbits and mice in which accelerated respiration and respiratory distress occurred (HSDB (2002)), it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |  |
H400 |
P273 P391 P501 |
From 96-hour LC50 = 1.0 mg/L for fish (Oryzias latipes) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 | |
H410 |
P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 because it is non-rapidly degradable (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 1985)) and 72-hour EC50 = 0.86 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007). If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 1 because it is non-rapidly degradable (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 1985)) and 96-hour LC50 = 1.0 mg/L for fish (Oryzias latipes) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007). It was classified in Category 1 by a comparison between the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/13 Addition of Rationale for the classification |