GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 105-38-4 |
| Chemical name | Vinyl propionate |
| Substance ID | 23A5016 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 2 |  |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 4.5 degrees C [closed-cup] (IUCLID (2000)) is < 23 degrees C, and an initial boiling point of 95 degrees C (Ullmanns (E) (6th、2003)) is > 35 degrees C, therefore, it corresponds to Category 2. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - |
The classification is not possible due to no data although it contains a chemical group related to self-reactivity (unsaturated bond). Besides, storage and transportation are conducted only under stable conditions because this substance tends to polymerize. Hydroquinone monomethyl ether is mostly used as a polymerization inhibitor (Hommel (1996)). |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 360 degrees C (Ullmanns (E) (6th、2003)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | On the basis of 3 LD50 values for rats (3000 mg/kg, 4670 mg/kg, and 4760 mg/kg) (IUCLID (2000)), it was classified as "Not classified" in the classification JIS (Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis of two LD50 values for rabbits (9170 mg/kg and 10000 mg/kg) (IUCLID (2000)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |  |
H331 |
P304+P340 P403+P233 P261 P271 P311 P321 P405 |
It was classified in Category 3 because LC50 values of > 5.3 to 20 mg/L/4h (> 1294 to 4884 ppm/4h) [OECD TG 403; GLP] (IUCLID (2000)) for rats correspond to Category 3 or 4 the higher level of which was adopted. Besides, a reference value of gasses (ppm) was applied because the toxicity value (5.3 to 20 mg/L) is lower than 90 % of the saturated vapour pressure concentration (197 mg/L). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
On the basis of results as "irritating" in two tests in which it was applied to rabbit skins, it was classified in Category 2. Besides, "not irritating" from an irritation score of 2/10 is reported in another test (IUCLID (2000)). |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | On the basis of not irritating results in all of 3 tests in which it was applied to rabbit eyes (IUCLID (2000)), it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | A maximization test using guinea pigs (OECD TG 406, GLP compliance) reports "not sensitizing" (IUCLID (2000)), however, it was classified as "Classification not possible" due to data from List 2 and unknown positive ratio. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, a negative in an Ames test (OECD TG 471) and a positive in a chromosomal aberration test using Chinese hamster V79 cells (OECD TG 473; GLP) were reported as in vitro tests (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
Lack of data. Besides, a 223-day diet administration test to female rats reports no adverse effects and an NOAEL of 2.56% (1280 mg/kg/day (IUCLID (2000)). In addition, bronchopneumonia is described as a finding in an oral administration in which rabbits were given 500 mg/kg/day for 24 times (IUCLID (2000)). Furthermore, torpor, drowsiness, diarrhea, and disequilibrium are observed in a test in which cats were orally administrated 1000 mg/kg/day for 10 or 38 times (IUCLID (2000)). But it was classified as "Classification not possible" because these data were from pieces of old literature in 1950-1952, the tests were not in accordance with Guideline, and details were unknown. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - |
H402 |
P273 P501 |
From 48-hour EC50 = 45.6mg/L for crustacea (Daphnia magna) (IUCLID, 2000), it was classified in Category 3. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - |
Reliable chronic toxicity data were not obtained. It was classified as "Not classified" due to rapid degradability (readily degradable, degradation by BOD: 93 % (the existing chemicals survey program, 2001)) and a low bioaccumulation estimate (logKow = 1.22 (PHYSPROP Database, 2012)), despite acute toxicity Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/13 Addition of Rationale for the classification |