GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 111-78-4 |
| Chemical name | Cycloocta-1,5-diene |
| Substance ID | 23A5022 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 33 degrees C [closed cup] (Hommel (1996)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 270 degrees C (Hommel (1996)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | On the basis of an LD50 value of 2381 mg/kg bw for rats (USEPA/HPV (2010), equivalent to List 1), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From an LD50 value of >3520 mg/kg bw and no mortality for rats (USEPA/HPV (2010)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 4 |  |
H332 |
P304+P340 P261 P271 P312 |
An LC50 value (4 hours) is judged to be within a range of Category 4 from mortality which was 0/6, 1/6, and 4/6 at 1400, 2700, and 4300 ppm respectively in rats in 4 hours exposure (USEPA/HPV (2010)). Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentrations (1400 to 4300 ppm) are lower than 90 % of the saturated vapour pressure concentration (8947 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
"Cyclooctadiene is corrosive to the skin, with necrosis of the epidermis and ulceration and marked inflammation of the dermis" (PATTY (5th, 2001)). In addition, very severe irritation occurred, and necrosis of the epidermis and ulceration and marked inflammation of the dermis in a histopathological examination were observed in a repeated application test in which 1 mL of the test substance was applied to rabbit skins for 6 hours a day for 3 days (USEPA/HPV (2010). Therefore, it was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Category 2B |
H320 |
P305+P351+P338 P337+P313 P264 |
From a result of a rabbit test in which irritation was shown immediately after application but the only produced conjunctivitis faded within 24 hours, the main effect was associated with the eyelids, which became red and swollen, and exuded a purulent discharge (USEPA/HPV (2010)), it was classified Category 2B. | |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Category 1 | |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
There is information that it is a skin sensitizer (PATTY (5th, 2001)). And a dermal sensitization test using guinea pigs reports that it is a potent skin sensitizer with 100% (10/10) positive sensitive reactions in a topical challenge test and 90% (9/10) in an intradermal challenge test (USEPA/HPV (2010)). Therefore, it was classified in Category 1. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
On the basis of a negative result in a micronucleus test (in vivo somatic cell mutagenicity test) using bone marrow cells after inhalation administration to rats (USEPA/HPV (2010)), it was classified as "Not classified." Besides, an Ames test and a chromosomal aberration test with human lymphocyte in in vitro tests reported both negative results (USEPA/HPV (2010)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
A combined repeated dose toxicity study with reproduction/development toxicity screening test by oral administration in rats (OECD TG 422: GLP) reports a decreased weight gain in parent animals as general toxicities at a high dose, no differences from a control group in parameters of mating and gestation, no adverse effects on sexual function and fertility (USEPA/HPV (2010)), and no effect on the number of litters and the number of survived offspring (USEPA/HPV (2010)). It was classified as "Classification not possible" due to insufficient data on developmental effects including teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） | |
H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
An inhalation test in which doses of 1400 to 4300 ppm (vapour) exposed to rats for 4 hours reports that all rats failed to respond to external sound stimuli by 3 hours into the exposure, ataxia and lethargy were observed, and deaths occurred at doses of 2700 ppm or higher (USEPA/HPV (2010)). Another test in which inhalation of a dose of 1500 ppm (vapour) for 6 hours a day continues for two days reports no deaths, but an action of arrest, lack of alerting response, and incordination after the first-day exposure (USEPA/HPV (2010)). On the basis of the observed symptoms, it was classified in Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (respiratory tract) |  |
H373 |
P260 P314 P501 |
Histological effects on a nasal cavity and a kidney, such as egeneration and necrosis of nasal olfactory epithelium, increased kidney weights, and increased hyaline droplets in the kidney, were observed at a dose of 500 ppm (2.21 mg/L) (converted to a 90-day equivalent: 0.34 mg/L), which corresponds to Category 2 in guidance values, in male rats in a 2-week inhalation (vapour) exposure (USEPA/HPV (2010)). The changes in the kidney were not used as bases for classification because they are specific for male rats and are considered to be inapplicable to human, but from the effects on the nasal cavity, it was classified in Category 2 (respiratory tract) because there are general cases that increases of exposure duration or concentration lead the lesions to lungs. Besides, a NOAEL of 600 mg/kg/day (converted to a 90-day equivalent: 360 mg/kg/day) reported in a combined repeated dose toxicity study with reproduction/development toxicity screening test by oral administration in rats (OECD TG 422: GLP) (USEPA/HPV (2010)), which is above upper limit (100 mg/kg/day) of a range of guidance values, corresponds to "Not classified" in an oral route. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |  |
H400 |
P273 P391 P501 |
From 48-hour EC50 = 0.87 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008), it was classified in Category1. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 | |
H410 |
P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2005)), and 72-hour NOEC＝0.93mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are lacking, then it is classified in Category 1 due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2005)), and 48-hour EC50 = 0.87 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008). It was classified in Category 1 by a comparison between the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/29 Addition of Rationale for the classification |